Electronic commerce has become indispensable for Small and Medium Enterprises (SMEs) around the world and it has special importance in developing countries to develop the capability of SMEs to compete and survive in this very competitive environment. The purpose is to determine the factors that affect the e-commerce by E-learning. An intensive review of the related literature was conducted to cover the variables of this study. Seven independent variables were developed as factors affect the adoption of e-commerce. These factors are expected advantage, ease of use, willingness of manager, customer need, cost, security, and company readiness. The findings show that expect advantage, ease of use, willingness of manager, customer need, security, and company readiness have significant and direct relationship with adoption of e-commerce. Cost was found to have significant but negative relationship with the adoption of e-commerce. E-learning enable to transfer the knowledge and skills to receivers in best way, however the rapid developing in technology lead widely using technology devises nowadays.