Familial Breast and Ovarian Cancer - Morrison, J. / Hodgson, V. / Haites, E. (eds.)
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This publication surveys the profound and far-reaching ramifications that have arisen from the very significant advances in our understanding of the genetic basis of familial breast and ovarian cancer. Written by international experts from Europe and North America, this book provides the busy clinician with a contemporary and wide-ranging guide to the latest developments in the diagnosis, genetics, screening, prevention and management of familial breast cancer. This area has advanced in knowledge so rapidly that this publication provides an unrivalled source of information including sections…mehr

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Produktbeschreibung
This publication surveys the profound and far-reaching ramifications that have arisen from the very significant advances in our understanding of the genetic basis of familial breast and ovarian cancer. Written by international experts from Europe and North America, this book provides the busy clinician with a contemporary and wide-ranging guide to the latest developments in the diagnosis, genetics, screening, prevention and management of familial breast cancer. This area has advanced in knowledge so rapidly that this publication provides an unrivalled source of information including sections on ethical and insurance issues and the different cultural differences in breast cancer. The use of recently devised cancer genetics clinics and different referral criteria and patterns to these clinics are detailed. The volume will be of immense value to all clinical geneticists, oncologists, and healthcare professionals involved in screening and counselling programmes.

Table of contents:
Part I. Molecular Biology and Natural History: 1. Introduction Patrick Morrison, Shirley Hodgson and Neva Haites; 2. Overview of clinical genetics of breast cancer Neva Haites and Helen Gregory; 3. Cowden syndrome and related disorders Charis Eng; 4. Overview of clinical genetics of ovarian cancer Pierre Chappuis and Will Foulkes; 5. Ovarian cancer as part of HNPCC and other hereditary colon cancer syndromes Hans Vasen and M. A. Nooy; 6. Natural history of hereditary breast cancer Dominique Stoppa-Lyonnet, Will Foulkes and Pierre Chappuis; 7. Pathology of the breast and ovary in mutation carriers Sunil Lakhani and Adrienne M. Flanagan; 8. Risk estimation for familial breast and ovarian cancer Jenny Chang-Claude and Heiko Becher; Part II. Screening: 9. Experience of setting up a cancer genetics service Jonathon Gray; 10. Referral criteria for cancer genetics clinics Diana Eccles; 11. Service aspects of cancer genetic clinics Neva Haites and Shirley Hodgson; 12. Cultural and education aspects influencing development of cancer genetics services in different European countries Shirley Hodgson; 13. Screening, detection and survival patterns of breast and other cancers in high risk families Pål Møller and Michael Steel; 14. Screening for familial ovarian cancer Barnaby Rufford, Usha Menon and Ian Jacobs; Part III. Management: 15. Management of BRCA 1/2 mutation carriers Pierre Chappuis and Will Foulkes; 16. Management of ovarian cancer Dirk Brinkman and Ian Jacobs; 17. Prophylactic mastectomy in mutation carriers Gareth Evans, Fiona Lalloo and Andrew Balidam; 18. Psychosocial aspects of genetic counselling Steven Sutton and Alison Bish; 19. BRCA 1 and 2 testing: uptake and its measurement Lucy Brooks and Gareth Evans; 20. Ethical aspects Patrick Morrison and Michael Steel; 21. Gene therapy of breast and ovarian cancer Richard Kennedy and Patrick Johnston; 22. Future directions Patrick Morrison, Shirley Hodgson and Neva Haites.

This publication surveys the profound and far-reaching ramifications that have arisen from advances in cancer genetics. Written by international experts from Europe and North America, this book provides the busy clinician with a contemporary and wide-ranging guide to the latest developments in the diagnosis, genetics, screening, prevention and management of familial breast cancer.

Surveys the diagnosis, genetics, screening, prevention and management of familial breast cancer.
Autorenporträt
Consultant clinical geneticist with a special interest in cancer genetics, in the Northern Ireland Regional Genetics Service. Qualified MB BCh BAO in 1986 and MD in 1993 from Queens'' University Belfast. Held molecular biology and neurogenetics research fellowships from the Royal College of Physicians in Ireland from 1991-1994. Member of the UK Government''s Human Genetics Commission, World Federation of Neurology Research Group in Huntingdon Disease, a steering group member on the International Collaborative group on hereditary breast and ovarian cancer (ICG-HBOC) and a council member of the Irish Society of Human Genetics. Involved in many other genetics and cancer societies. Published over 100 peer-reviewed articles on all aspects of genetics, particularly late onset neurogenetics diseases, familial cancers and insurance isuues.