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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Familial renal amyloidosis (or familial visceral amyloidosis, or hereditary amyloid nephropathy) is a form of amyloidosis primarily presenting in the kidney.It is associated with fibrinogen alpha chain, apolipoprotein A1, and lysozyme.It is also known as "Ostertag" type, after B. Ostertag, who characterized it in 1932 and 1950.As a major component of the high-density lipoprotein complex ("good cholesterol"), ApoA-I helps to clear cholesterol from arteries. Five of nine men found to carry a mutation (E164X) who were at least 35 years of age had developed premature coronary artery disease. One of four mutants of ApoA-I is present in roughly 0.3% of the Japanese population, but is found 6% of those with low HDL cholesterol levels.