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Environmental pollution is one of the major problems in many parts overall the world. Heavy metals considered as a main sources of environmental pollution. Several environmental toxins such as lead, cadmium and mercury may be of importance in promoting and accelerating of many disease. So, the present work study A) contamination of different types of bread samples (shamey, balady, bran bread) collected from El-Mansoura city and its raw materials with some heavy metals i.e. (Cu, Zn, Pb, Cd and Hg), B) contamination of Bolti fish and water samples obtained from different areas (El- Manzalah Lake, Kafr El-Sheik farm and Talkha Market),C) Biological experiment using fed animal rats with naturally contaminated fish and bread with Pb and Cd, drinking water contain pure Pb and/or Cd with the same limits found in the contaminated fish and bread and the permissible limits as recommended by FAO (1983). The study could conclud that: The foods and its products must be protected from the contamination by heavy metals especially Cd, Pb because they have highly toxic effect through the caring by processing steps and the handling/marketing.