Fc Mediated Activity of Antibodies

Structural and Functional Diversity
Herausgegeben:Ravetch, Jeffrey V.; Nimmerjahn, Falk

• Gebundenes Buch

Produktbeschreibung

This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.

Produktdetails

• Current Topics in Microbiology and Immunology 423
• Verlag: Springer / Springer International Publishing / Springer, Berlin
• Artikelnr. des Verlages: 978-3-030-31052-3
• 1st ed. 2019
• Seitenzahl: 160
• Erscheinungstermin: 19. September 2019
• Englisch
• Abmessung: 241mm x 160mm x 15mm
• Gewicht: 356g
• ISBN-13: 9783030310523
• ISBN-10: 3030310523
• Artikelnr.: 57413472

Autorenporträt

Jeffrey V. Ravetch Theresa and Eugene M. Lang Professor Department Leonard Wagner Laboratory of Molecular Genetics and Immunology Rockefeller University 1230 York Avenue, Box 98 New York, NY 10021, USA [e-mail] Falk Nimmerjahn Professor for Immunology and Genetics Chairman of the Institute of Genetics Head of the Department of Biology Department of Biology University of Erlangen-Nuernberg Erwin-Rommelstr. 3 91058 Erlangen, Germany [e-mail]

Inhaltsangabe

IgG Fc receptors: evolutionary considerations.- Role of FcgRs in Antibody Based Cancer Therapy.- Anti-inflammatory Activity of IgG-Fc.- IgG Fc glycosylation in human immunity.- IgE Glycosylation in Health and Disease.- Immune Complex Vaccination.- Fc receptors in anti-microbial protection.