Fc Mediated Activity of Antibodies
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This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer…mehr

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Produktbeschreibung
This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.

Autorenporträt
Jeffrey V. Ravetch Theresa and Eugene M. Lang Professor Department Leonard Wagner Laboratory of Molecular Genetics and Immunology Rockefeller University 1230 York Avenue, Box 98 New York, NY 10021, USA ravetch@mail.rockefeller.edu Falk Nimmerjahn Professor for Immunology and Genetics Chairman of the Institute of Genetics Head of the Department of Biology Department of Biology University of Erlangen-Nuernberg Erwin-Rommelstr. 3 91058 Erlangen, Germany falk.nimmerjahn@fau.de