Every physician, regardless of his specialization, must know the basic principles of differential diagnosis, because untimely recognition of serious clinical symptoms associated with pain syndrome in the heart region, threatening the health and sometimes life of the patient, are of paramount importance for any clinician.To properly understand the essence of the pain syndrome, it is necessary to have the necessary knowledge about the development of clinical manifestations of various CVDs and their diagnostic criteria.Based on the above, we felt it necessary to provide more detailed information on the nature of the clinical course and diagnostic methods in various SSc.