Fermented Cholesterol Lowering Drug (Lovastatin) - Javed, Sadia;Meraj, Munazzah;Anwer Bukhari, Shazia
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Lovastatin is an inhibitor of 3-hydroxy-3methylglutaryl-coenzyme A reductase (HMG-CoA reductase), an enzyme that catalyzes the conversion of HMG-CoA to mevalonate. In western countries, the most significant cause of death is the coronary heart disease and progression of atherosclerosis which is mostly related to the hypercholesterolemia. Approximately 10.8% of all deaths are caused due to this disease. Coronary heart disease actually is a wide assortment of diseases. It has been reported that 30 million people have familial hypercholesterolemia worldwide, but less than 1% of cases are…mehr

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Produktbeschreibung
Lovastatin is an inhibitor of 3-hydroxy-3methylglutaryl-coenzyme A reductase (HMG-CoA reductase), an enzyme that catalyzes the conversion of HMG-CoA to mevalonate. In western countries, the most significant cause of death is the coronary heart disease and progression of atherosclerosis which is mostly related to the hypercholesterolemia. Approximately 10.8% of all deaths are caused due to this disease. Coronary heart disease actually is a wide assortment of diseases. It has been reported that 30 million people have familial hypercholesterolemia worldwide, but less than 1% of cases are diagnosed in most countries. A lab experiment was carried out for fungal production of lovastatin in solid state fermentation. Fermentation medium was optimized by optimizing the fermentation parameters (pH, temperature, inoculum size, moisture contents etc.).
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Autorenporträt
Dr. Sadia Javed, PhD Biochemistry, studied at University of Agriculture, Faisalabad. Assistant Professor at Government College University, Faisalabad, Pakistan.