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Bullous fixed erythema pigmentosum is a severe drug-induced toxidermia requiring specialized management. The aim of our study was to determine the epidemiological, clinical, therapeutic and evolutionary characteristics of erythema pigmentosum fixe bullosa.We carried out a retrospective descriptive study in the dermatology department of the Habib Thameur Hospital in Tunis over a 17-year period from January 2000 to December 2016 collating 16 cases of erythema pigmentosum fixe bullosa confirmed histologically and by a pharmacovigilance survey. In total, we collected 16 cases of bullous erythema pigmentosum fixe. The mean age of our patients was 42.8 years, with a M/F sex ratio of 1.23. Bullous EPF was localized in 8 cases and generalized in 8. Mucocutaneous involvement was present in 6 patients, isolated cutaneous in 7 and isolated mucosal in 3. Two patients had systemic signs such as fever and altered general condition. Eight patients were treated with dermocorticoids alone, and eight with general corticosteroids and dermocorticoids. Our patients progressed well.