Jun-Ichi Yoshida

Flash Chemistry

Fast Organic Synthesis in Microsystems

• Gebundenes Buch

Produktbeschreibung

Have you ever wished you could speed up your organic syntheses without losing control of the reaction? Flash Chemistry is a new concept which offers an integrated scheme for fast, controlled organic synthesis. It brings together the generation of highly reactive species and their reactions in microsystems to enable highly controlled organic syntheses on a preparative scale in timescales of a few seconds or less.

Flash Chemistry - Fast Chemical Reactions in Microsystems is the first dedicated book to describe this exciting new technique, and is an essential introduction for anyone working in organic synthesis, process chemistry, chemical engineering and physical organic chemistry concerned with fundamental aspects of chemical reactions and synthesis and the production of organic compounds.

Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 248
• Erscheinungstermin: 1. Dezember 2008
• Englisch
• Abmessung: 233mm x 156mm x 20mm
• Gewicht: 490g
• ISBN-13: 9780470035863
• ISBN-10: 0470035862
• Artikelnr.: 25055426

Autorenporträt

Professor Yoshida is head of the synthetic organic chemistry group at Kyoto University Graduate School of Engineering. His research activities concentrate on the development of methods to control and direct organic reactions.

Inhaltsangabe

1. Introduction. 1.1 Flask chemistry. 1.2 Flash chemistry. 1.3 Flask
chemistry or flash chemistry. 2. The Background to Flash Chemistry. 2.1 How
do chemical reactions take place?. 3. What is Flash Chemistry?. 4. Why is
Flash Chemistry Needed?. 4.1 Chemical reaction, an extremely fast process
at molecular level. 4.2 Rapid construction of chemical libraries. 4.3 Rapid
synthesis of radioactive PET probes. 4.4 On-demand rapid synthesis in
industry. 4.5 Conclusions. 5. Methods of Activating Molecules. 5.1 Thermal
activation of organic molecules. 5.2 Photochemical activation. 5.3
Electrochemical activation. 5.4 Chemical activation. 5.5 Accumulation of
reactive species. 5.6 Continuous generation of reactive species in a flow
system. 5.7 Interconversion between reactive species. 5.8 Conclusions. 6.
Methods of Activating Molecules. 6.1 Mixing. 6.2 Temperature control. 6.3
Residence time control. 6.4 Conclusions. 7. Microfluidic Devices and
Microflow Systems. 7.1 Brief history. 7.2 Characteristic features of
microflow systems. 7.3 Microstructured fluidic devices. 7.4 Conclusions. 8.
Applications of Flash Chemistry in Organic Synthesis. 8.1 Highly exothermic
reactions which are difficult to control in macrobatch reactors. 8.2
Reactions in which a reactive intermediate easily decomposes in macrobatch
reactors. 8.3 Reactions the products of which easily decompose in
macrobatch reactors. 8.4 Reactions in which undesired byproducts are
produced in the subsequent reactions in macrobatch reactors. 8.5 Reactions
that can be accelerated using microflow systems. 8.6 Summary. 9. Polymer
Synthesis Based on Flash Chemistry. 9.1 Introduction. 9.2 Chain-growth
polymerization and step-growth polymerization. 9.3 Molecular weight and
molecular-weight distribution. 9.4 Cationic polymerization. 9.5
Free-radical polymerization. 9.6 Summary. 10. Industrial Applications of
Flash Chemistry. 10.1 Synthesis of diarylethene as photochromic compound
(micrometer size single reactor). 10.2 Synthesis of pharmaceutically
interesting spiro lactone fragment of nueropeptide Y (Millimeter size
single reactor). 10.3 Grignard Exchange Process (Internal numbering-up).
10.4 Radical Polymerization Process (Numbering-up). 10.5 Other examples of
industrial applications of flash chemistry . 10.6 Flash chemistry as a
powerful way of sustainable chemical synthesis. 11. Outlook of Flash
Chemistry.