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Ciprofloxacin hydrochloride is a second generation antibiotic and a BCS class II drug. It was taken as a model drug to prepare Floating Bio-Adhesive tablets. This drug has the maximum therapeutic window in the upper stomach, so controlled drug release with the optimum retentive formulation in the upper stomach would be an ideal formulation. We tried to prepare floating bioadhesive tablets using three principal polymers, such as HPMCK15M (08%, 12% & 16%), carbopol 934P (06%, 09% & 12%) and CMC (03%, 06% & 09%). Total 13 formulations were designed (CF1 to CF13) and various evaluation parameters were studied. After a comprehensive analysis, it was confirmed that CF13 formulation was emerging out to be an optimum formulation.