Sea level rise has been accelerating worldwide and consequently in South Florida. By 2060, scientists believe that the sea level in the city of Key West will reach between 22.86 to 60.96 centimeters (Strauss et al. 2012). The effects of a rapidly rising sea level are clear in coastal cities; higher storm surges, higher tides and frequent flooding including the complete inundation of some low lying cities. In this book, the sea level measurements of four Floridian coastal cities (including Key West) are collected in order to study their trend in sea level rise over the past 100 years. We developed several models to describe this rise as well as study the difference in sea-level rise between the four cities.