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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Fluoride induced nephrotoxicity is kidney injury due to toxic levels of serum fluoride, commonly due to metabolism of fluoride-containing drugs, such as methoxyflurane, releasing inorganic fluoride inside the body. The kidney injury is characterised by failure to concentrate urine, leading to polyuria, and subsequent dehydration with hypernatremia and hyperosmolarity. Inorganic fluoride inhibits adenylate cyclase activity required for antidiuretic hormone effect on the distal convoluted tubule of the kidney. Fluoride also stimulates intrarenal vasodilation, leading to increased medullary blood flow, which interferes with the counter current mechanism in the kidney required for concentration of urine.