Fluorinated compounds have distinctive desirable properties suitable for use in pharmaceuticals and agrichemicals, especially their ability to penetrate the cell membrane barrier for drug absorption. This essential reference provides the latest state-of-the-art information on key application areas within fluorine chemistry. With contributions from experts from both industry and academia, the book covers the chemistry, synthesis and applications of fluorinated heterocycles with chapters on three-, four-, five-, six- and seven-membered fluorine-containing heterocycles, fluorinated nucleosides, and fluorointermediates and fluoropolymers.…mehr
Fluorinated compounds have distinctive desirable properties suitable for use in pharmaceuticals and agrichemicals, especially their ability to penetrate the cell membrane barrier for drug absorption. This essential reference provides the latest state-of-the-art information on key application areas within fluorine chemistry. With contributions from experts from both industry and academia, the book covers the chemistry, synthesis and applications of fluorinated heterocycles with chapters on three-, four-, five-, six- and seven-membered fluorine-containing heterocycles, fluorinated nucleosides, and fluorointermediates and fluoropolymers.
Viacheslav A. Petrov is a Research Fellow with DuPont Central Research and Development in Wilmington, Delaware.
Inhaltsangabe
PREFACE. CONTRIBUTORS. INTRODUCTION: NOMENCLATURE OF POLYFLUORINATED HETEROCYCLES. PART I SYNTHESIS AND CHEMISTRY OF FLUORINATED HETEROCYCLES. 1 Fluorinated Three-Membered Ring Heterocycles (David M. Lemal and Sudharsanam Ramanathan). 2 Fluorinated Four-Membered Heterocycles (Roman B. Larichev and Viacheslav A. Petrov). 3 Fluorinated Five-Membered Nitrogen-Containing Heterocycles (Kenneth L. Kirk). 4 Fluorinated Five-Membered Heterocycles Containing Oxygen, Sulfur, Selenium, and Phosphorus (Yuriy Shermolovich). 5 Synthesis of Fluorinated Sugars from Fluorine-Containing Synthons (Xiao-Long Qiu and Feng-Ling Qing). 6 Synthesis of Ring-Fluorinated Pyridines (Anatoliy M. Shestopalov, Alexander A. Shestopalov, Lyudmila A. Rodinovskaya, and Anna V. Gromova). 7 Synthesis and Chemical Transformation of Six-Membered Aromatic Heterocycles Containing Perfluoroalkyl Groups (Viacheslav A. Petrov). 8 Perfluorinated Six-Membered Aromatic Heterocycles Containing One or More Heteroatom (Graham Sandford). 9 Perfluorinated Nonaromatic Heterocycles (Viacheslav A. Petrov). 10 Seven-Membered and Larger Ring-Fluorinated Heterocycles (Viacheslav A. Petrov). PART II APPLICATION OF FLUORINATED HETEROCYCLIC MATERIALS. 11 Agricultural Products Based on Fluorinated Heterocyclic Compounds (Wonpyo Hong). 12 Pharmaceuticals Containing Fluorinated Heterocyclic Compounds (Kenji Uneyama and Kenji Sasaki). 13 Practical Uses of Fluorinated Heterocycles (Paul R. Resnick). Index.
PREFACE. CONTRIBUTORS. INTRODUCTION: NOMENCLATURE OF POLYFLUORINATED HETEROCYCLES. PART I SYNTHESIS AND CHEMISTRY OF FLUORINATED HETEROCYCLES. 1 Fluorinated Three-Membered Ring Heterocycles (David M. Lemal and Sudharsanam Ramanathan). 2 Fluorinated Four-Membered Heterocycles (Roman B. Larichev and Viacheslav A. Petrov). 3 Fluorinated Five-Membered Nitrogen-Containing Heterocycles (Kenneth L. Kirk). 4 Fluorinated Five-Membered Heterocycles Containing Oxygen, Sulfur, Selenium, and Phosphorus (Yuriy Shermolovich). 5 Synthesis of Fluorinated Sugars from Fluorine-Containing Synthons (Xiao-Long Qiu and Feng-Ling Qing). 6 Synthesis of Ring-Fluorinated Pyridines (Anatoliy M. Shestopalov, Alexander A. Shestopalov, Lyudmila A. Rodinovskaya, and Anna V. Gromova). 7 Synthesis and Chemical Transformation of Six-Membered Aromatic Heterocycles Containing Perfluoroalkyl Groups (Viacheslav A. Petrov). 8 Perfluorinated Six-Membered Aromatic Heterocycles Containing One or More Heteroatom (Graham Sandford). 9 Perfluorinated Nonaromatic Heterocycles (Viacheslav A. Petrov). 10 Seven-Membered and Larger Ring-Fluorinated Heterocycles (Viacheslav A. Petrov). PART II APPLICATION OF FLUORINATED HETEROCYCLIC MATERIALS. 11 Agricultural Products Based on Fluorinated Heterocyclic Compounds (Wonpyo Hong). 12 Pharmaceuticals Containing Fluorinated Heterocyclic Compounds (Kenji Uneyama and Kenji Sasaki). 13 Practical Uses of Fluorinated Heterocycles (Paul R. Resnick). Index.
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