Hyderabad Karnataka Region (India) - a boon for indigenous knowledge has a glorious historical past, rich traditional customs and treasure of folk medicinal plants. Folk medicine is an unofficial health-related practice that has traditionally existed, and is learnt informally and orally through observations and demonstrations. Hyderabad Karnataka Region especially among different strata groups, folk medicine is still practiced in rural areas. This has been untraced and lacks proper documentation, including the rare manuscripts that deal with folk medicine. Libraries have a greater role to play in preserving the traditional knowledge, as they deal with every bit of universal domain of knowledge and hence occupy great relevance.