Ksenia Guseva

Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane

• Gebundenes Buch

Produktbeschreibung

With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behavior of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process.

Produktdetails

• Springer Theses
• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 80084537, 978-3-642-23987-8
• 2012
• Seitenzahl: 92
• Erscheinungstermin: 2. Oktober 2011
• Englisch
• Abmessung: 241mm x 160mm x 10mm
• Gewicht: 278g
• ISBN-13: 9783642239878
• ISBN-10: 3642239870
• Artikelnr.: 33837952

Inhaltsangabe

Introduction.- The Role of Fragmentation on the Formation of Homomeric Protein Complexes.- Collective Response of Self-organised Clusters of Mechanosensitive Channels.- Assembly and Fragmentation of Tat Pores.- Conclusion.