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Lamotrigine comes under the category of anti-epileptic drug. It is a BCS class II drug which is insoluble in water and its half-life is 24-25 hours with 90% bioavailability. To obtain an enhanced in-vitro dissolution rate of Lamotrigine by using Liquisolid technique and Liquisolid tablets were optimized by QbD-DoE approach 32 full factorial design using Design Expert Software. All prepared liquisolid batches were subjected to weight variation, drug content uniformity, hardness, friability test, and disintegration test and dissolution tests. Liquisolid systems were also tested for DSC, FT-IR. From result of check point analysis of design data, LMLCODT1 shows higher Drug release at LAMOTRIGINE less wetting time and disintegrating time (5.24 sec) which enhancing solubility of Lamotrigine by 4.73 mg/ml. Hence, this research work may be useful to formulate Orodispersible Tablets using Liquisolid Technique which may give rapid onset of action by rapid absorption, maximize efficacy, reduce dose and dose frequency & hence increase patient Compliance.