Formulation & Development of Rosuvastatin Fast Dissolving Tablets - Gopaiah, Kurra Venkata
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Floating systems or hydrodynamically controlled systems are low-density systems that have sufficient buoyancy to float over the gastric contents and remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. While the system is floating on the gastric contents, the drug is released slowly at the desired rate from the system. After the release of the drug, the residual system is emptied from the stomach. This results in an increased GRT and better control of the fluctuations in plasma drug concentration. However, besides a minimal gastric content…mehr

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Produktbeschreibung
Floating systems or hydrodynamically controlled systems are low-density systems that have sufficient buoyancy to float over the gastric contents and remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. While the system is floating on the gastric contents, the drug is released slowly at the desired rate from the system. After the release of the drug, the residual system is emptied from the stomach. This results in an increased GRT and better control of the fluctuations in plasma drug concentration. However, besides a minimal gastric content needed to allow the proper achievement of the buoyancy retention principle, a minimal level of floating force (F) is also required to keep the dosage form reliably buoyant on the surface of the meal. Many buoyant systems have been developed based on granules, powders, capsules, tablets, laminated films, and hollow microspheres.
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Autorenporträt
The author currently working as Assistant Professor in K L E F, K L College of Pharmacy, Guntur. Submitted thesis work for Ph.D. to JAIPUR NATIONAL UNIVERSITY-JAIPUR. Attended and participated in various National & International Conferences, Seminar & also act as Scientific Evaluator in various National & International Conferences.