FORMULATION AND CHARACTERIZATION oF NICOTINE MOUTH SPRAY - Mehta, Farhad F;Agrawal, Kajal;Jain, Deepti
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The main aim of our project was to formulate and characterize nicotine mouth sprays. Millions o f people have died and suffered from various diseases like cancer, stroke, blindness, heart problem, and many other chronic diseases by the consumption of raw tobacco and smoking cigarettes.We have developed a nicotine mouth spray formulation as a type of nicotine replacement therapy (NRT) to aid in smoking cessation. This spray can help reduce cravings and alleviate withdrawal symptoms for those who are trying to quit smoking or decrease their tobacco consumption.The optimized formula was generated…mehr

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Produktbeschreibung
The main aim of our project was to formulate and characterize nicotine mouth sprays. Millions o f people have died and suffered from various diseases like cancer, stroke, blindness, heart problem, and many other chronic diseases by the consumption of raw tobacco and smoking cigarettes.We have developed a nicotine mouth spray formulation as a type of nicotine replacement therapy (NRT) to aid in smoking cessation. This spray can help reduce cravings and alleviate withdrawal symptoms for those who are trying to quit smoking or decrease their tobacco consumption.The optimized formula was generated by the Box- Behnken design under the response surface methodology by the DoE method. Mucoadhesion studies were carried out on the prepared optimized formulation to verify the theoretical prediction. The observed values 0.318 kg was in close agreement with the model prediction: bioadhesive strength- 0.335 kg.These finding reveal that the nicotine mouth spray solution/dispersion would be considered as a successful substitute to various market available NRT formulations, due to its rapid absorption characteristics, which would help general public to quit smoking more effectively.
Autorenporträt
Dr Farhad F Mehta, working as Assistant Professor (C) at School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishvavidyalaya, Bhopal, M P., India. He has published more than 16 research, review papers and authored 4 books in various reputed peer reviewed journals/publications and has been granted more than 50 patents, design registrations.