Andere Kunden interessierten sich auch für
![Formulation & Evaluation of Floating Matrix Tablets of Levofloxacin]( "Formulation & Evaluation of Floating Matrix Tablets of Levofloxacin")
Formulation & Evaluation of Floating Matrix Tablets of Levofloxacin35,99 €![CINNARIZINE: Fast Dissolving Tablet]( "CINNARIZINE: Fast Dissolving Tablet")
CINNARIZINE: Fast Dissolving Tablet39,99 €![Formulation and Evaluation of Floating Tablets of Quetiapine Fumarate]( "Formulation and Evaluation of Floating Tablets of Quetiapine Fumarate")
Formulation and Evaluation of Floating Tablets of Quetiapine Fumarate26,99 €![Formulation and In-vitro Evaluation of Alfuzosin HCl Floating Tablet]( "Formulation and In-vitro Evaluation of Alfuzosin HCl Floating Tablet")
Formulation and In-vitro Evaluation of Alfuzosin HCl Floating Tablet44,99 €![Sustain Release Matrix Tablet of Cinnarizine]( "Sustain Release Matrix Tablet of Cinnarizine")
Sustain Release Matrix Tablet of Cinnarizine35,99 €![GASTRORETENTIVE FLOATING DRUG DELIVERY SYSTEM OF ZALEPLON TABLETS]( "GASTRORETENTIVE FLOATING DRUG DELIVERY SYSTEM OF ZALEPLON TABLETS")
GASTRORETENTIVE FLOATING DRUG DELIVERY SYSTEM OF ZALEPLON TABLETS32,99 €![Formulation and Evaluation of Floating In-Situ Gel of Methotrexate]( "Formulation and Evaluation of Floating In-Situ Gel of Methotrexate")
Formulation and Evaluation of Floating In-Situ Gel of Methotrexate39,99 €
Cinnarizine, a piperazine derivative with anti-histaminic activity finds its major use in control of vomiting due to motion sickness. It has a short half-life of 3-6 hrs. & the usual dosage regimen is 75 mg twice or three times a day for adults. The floating tablets of cinnarizine were formulated using varying concentration of HPMC K4M & effervescent agents by wet granulation technique. The granules were evaluated for angle of repose, bulk density, tapped density, Carr s index, Hausner s ratio & drug content. The tablets were evaluated for thickness, hardness, weight variation test, friability, in vitro buoyancy & in vitro dissolution study. A 3 Square factorial design was used to study the effect of HPMC K4M & citric acid on lag time, floating time & percentage cumulative release. The responses were analyzed using ANOVA & by the predictive equation, it was found that the concentration of HPMC K4M & citric acid significantly affected all the response parameters. The obtained model was validated & optimized formulation was prepared as suggested by the software. All the predicted values of responses were found to be closed to the observed values.