Formulation and Evaluation of Fast Dissolving Film of Chlorpromazine - Pandit, Vinay;Sharma, Priyanka;Ashawat, M. S.
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Emesis is the involuntary and forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose. Receptors on the floor of the ventricle of the brain represent a chemo-receptor trigger zone, known as the area postrema, stimulation of which can lead to vomiting. Chlorpromazine HCl is formulated as a sublingual film. The films formed by HPMC K-15 at a concentration of 120 mg showed the desirable character for a sublingual film. The optimized films formed were subjected to evaluation parameters viz. Tensile Strength, Disintegration, In-vitro dissolution, Ex-vivo…mehr

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Produktbeschreibung
Emesis is the involuntary and forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose. Receptors on the floor of the ventricle of the brain represent a chemo-receptor trigger zone, known as the area postrema, stimulation of which can lead to vomiting. Chlorpromazine HCl is formulated as a sublingual film. The films formed by HPMC K-15 at a concentration of 120 mg showed the desirable character for a sublingual film. The optimized films formed were subjected to evaluation parameters viz. Tensile Strength, Disintegration, In-vitro dissolution, Ex-vivo Permeation studies and In-vivo studies and the results complied with the available statistical data. In-vitro dissolution studies were analyzed and Higuchi model was found to be the best fit model for In-vitro dissolution studies with a regression value of 0.9248. Ex-vivo permeation studies showed fivefold enhanced permeation of drug from films as compared to pure drug. In conclusion, a sublingual film of Chlorpromazine HCl may result in better patient compliance, quick onset of action and enhanced bio-availability.
Autorenporträt
Dr. Vinay Pandit is werkzaam als professor en hoofd van de afdeling Farmacie, Laureaatsinstituut voor de farmacie. Zijn huidige onderzoeksgebied is Novel drug delivery system en fast dissolving technology. Hij heeft een aantal publicaties in gerenommeerde nationale en internationale tijdschriften.