Formulation and Evaluation of Transdermal Patches of Ibuprofen - Nampelly, Karnakar;Hechhu, Ramana
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In the present study, Transdermal drug delivery of Ibuprofen was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route. Matrix type of Transdermal patches were developed by using polymers Eudragit-L100, HPMC K4M and HPMC K15M. Transdermal patches were prepared by employing solvent casting method. Propylene glycol and Tween80 were selected as Permeation enhancer and Plasticizer. Formulations were prepared with the varying concentrations polymers ranging from F1-F12, and all the formulations were evaluated for various physical parameters,…mehr

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Produktbeschreibung
In the present study, Transdermal drug delivery of Ibuprofen was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route. Matrix type of Transdermal patches were developed by using polymers Eudragit-L100, HPMC K4M and HPMC K15M. Transdermal patches were prepared by employing solvent casting method. Propylene glycol and Tween80 were selected as Permeation enhancer and Plasticizer. Formulations were prepared with the varying concentrations polymers ranging from F1-F12, and all the formulations were evaluated for various physical parameters, In-vitro drug release studies by using dialysis membrane. Among all the formulations F6 formulation was found to be best and shown 96.5% drug release in 12 hours. For F6 formulation release kinetics were applied and it was observed that the formulation was following peppas mechanism of drug release. Drug excipient compatibility studies were carried out by using FTIR, and it was observed that they were no interactions.
Autorenporträt
Dr. Karnakar Nampelly, M.Pharm, Ph.D, arbeitet als Assistenzprofessor, HOD, Abteilung für Pharmazie im Venkateshwara Institute of Pharmaceutical Science, Nalgonda, Indien. Er verfügt über einen ausgezeichneten akademischen Hintergrund und praktische Erfahrung auf dem Gebiet der Pharmazie und hat 30 Projekte für UG- und PG-Studenten geleitet und 10 Forschungspublikationen veröffentlicht.