Formulation Development of Extended Released Rifaximin Micro-particles - Bhise, Kiran;Karanje, Rohan
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This book addresses the formulation and process design aspects of extended release micro particles of BCS class IV drug Rifaximin through cyclodextrin complexation and extending the drug release by Eudragit L -100 enteric coating. The concept of surface response methodology was used in the selection of optimized batch that was further evaluated for various parameters. The data supports an improvement in aqueous solubility of BCS class IV drugs through cyclodextrin complexes. The release of such inclusion complexes can be retarded for 8 hrs by enteric coating.

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Produktbeschreibung
This book addresses the formulation and process design aspects of extended release micro particles of BCS class IV drug Rifaximin through cyclodextrin complexation and extending the drug release by Eudragit L -100 enteric coating. The concept of surface response methodology was used in the selection of optimized batch that was further evaluated for various parameters. The data supports an improvement in aqueous solubility of BCS class IV drugs through cyclodextrin complexes. The release of such inclusion complexes can be retarded for 8 hrs by enteric coating.
Autorenporträt
Kiran Sanjay Bhise, M.Pharm PhD, Principal & Professor Allana College of Pharmacy, Pune, India has over 30 referred publications 2 Indian Patents under examination state to her credit.She has guided 50 postgraduate and 2 PhDS.Her area of research includes herbal nano and microparticulate DDS with major emphasis on skin disease,cancer,GIT disorders.