Formulation, Development of Mesalamine Tablet for Colon Targeting - Shinde, Anilkumar;Tamboli, Firoj;More, Harinath
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The objective of present work was to prepare colon-specific delivery systems for 5-aminosalicylic acid (5-ASA) using fenugreek gum and chitosan as a carrier target to the colon. Methods: Core tablets containing 5-ASA were prepared by wet granulation with using polyvinyl pyrolidone (PVP) as a binder and sodium starch glycolate as a super disintegrant. The prepared granules were evaluated for the angle of repose, compressibility index and Hausner's ratio. The prepared tablets were evaluated the hardness, friability, weight variation and disintegration studies. The core tablets were coated with…mehr

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Produktbeschreibung
The objective of present work was to prepare colon-specific delivery systems for 5-aminosalicylic acid (5-ASA) using fenugreek gum and chitosan as a carrier target to the colon. Methods: Core tablets containing 5-ASA were prepared by wet granulation with using polyvinyl pyrolidone (PVP) as a binder and sodium starch glycolate as a super disintegrant. The prepared granules were evaluated for the angle of repose, compressibility index and Hausner's ratio. The prepared tablets were evaluated the hardness, friability, weight variation and disintegration studies. The core tablets were coated with the concentration of 2%, 5%, and 7% in the ratio of 50:50, 40:60, 60:40, 70:30 and 30:70 of fenugreek gum and chitosan. The enteric coated tablets were characterized for the in vitro disintegration, and dissolution. The drug polymer compatibility studies were determined by using FT-IR study and found out no interaction between the drug and polymers. Results: The formation of complexes betweenfenugreek gum and chitosan prevents the drug release in the stomach. The tablets coated with 7% concentration solutions in the ratio 70:30 (Fenugreek gum: Chitosan) shows better swelling property.
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Autorenporträt
Dr. Anilkumar J. Shinde, M.Pharm Ph.D (Pharmacy) has 26 years experience in teaching & researching. Presently he is working as Associate Professor in Pharmaceutics Department at Bharati Vidyapeeth College of Pharmacy, Kolhapur. He has 66 research papers & 5 review articles published in National & International Journals. One Nigerian patent.