Formulation development of taste masked Cefuroxime Axetil - Sayyed, Nilofer;Bhise, Kiran
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The objective of the present study was to address challenges in research and development associated with the bitter taste and poor aqueous solubility of Cefuroxime Axetil. The inclusion complex of drug and HP- -Cyclodextrin and mouth dissolving tablets were prepared. Bitter taste threshold, DSC, PXRD, saturation solubility, in-vitro dissolution studies were carried out for pure drug CA, commercial tablet CEFTUM and CA loaded MDTs. The results support an addition of banana starch to CA-HP CD inclusion complexes can efficiently aid as an antidiarrheal agent and mask the bitter taste of CA.

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Produktbeschreibung
The objective of the present study was to address challenges in research and development associated with the bitter taste and poor aqueous solubility of Cefuroxime Axetil. The inclusion complex of drug and HP- -Cyclodextrin and mouth dissolving tablets were prepared. Bitter taste threshold, DSC, PXRD, saturation solubility, in-vitro dissolution studies were carried out for pure drug CA, commercial tablet CEFTUM and CA loaded MDTs. The results support an addition of banana starch to CA-HP CD inclusion complexes can efficiently aid as an antidiarrheal agent and mask the bitter taste of CA.
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Autorenporträt
Ms. Nilofer Sayyed has completed her M Pharmacy under the guidance of Dr. Kiran Bhise in Pharmaceutics branch and is currently working at Allana College of Pharmacy, Pune as Assistant Professor in Pharmaceutics.