Formulation of Thymoquinone Nanoparticles and its in-vitro Evaluation - Alam, Sanjar
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Hydrophobic drugs delivered orally encounter permeabil ity problems and hence poor bioavailability. They undergo chemical and enzymatic degradation in the gastrointestinal tract and show extensive hepatic first-pass metabolism. Similarly, various additional factors hinder drug discovery and the development of an effective delivery of different therapeutic molecules. Thymoquinone (THQ) a major active lipophilic component of Nigella Sativa (Ranunculaceae) was reported to have many pharmacological qualities such as its immu-nomodulation, anticancer, anti-inflammatory and antioxidant effects.…mehr

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Produktbeschreibung
Hydrophobic drugs delivered orally encounter permeabil ity problems and hence poor bioavailability. They undergo chemical and enzymatic degradation in the gastrointestinal tract and show extensive hepatic first-pass metabolism. Similarly, various additional factors hinder drug discovery and the development of an effective delivery of different therapeutic molecules. Thymoquinone (THQ) a major active lipophilic component of Nigella Sativa (Ranunculaceae) was reported to have many pharmacological qualities such as its immu-nomodulation, anticancer, anti-inflammatory and antioxidant effects. Physicochemical characterization of THQ was done on the basis of organoleptic properties, solubility, loss on drying, partition coefficient, IR spectroscopy and differential scanning calorimetry. On the basis of these test the drug sample THQ was found to be authentic and pure. An analytical method using RP-HPLC was developed and validated for determining in vitro release and permeation study. Chitosan nanoparticles (NP) were prepared according to ionic gelation method.
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Autorenporträt
Le Dr. Sanjar Alam est un enseignant et chercheur jeune et dynamique qui a douze ans d'expérience dans la recherche et l'enseignement et a publié plus de trente articles de recherche et de synthèse dans des revues internationales et nationales réputées. Il a obtenu son doctorat du département de pharmacie de Jamia Hamdard. Il travaille actuellement comme professeur associé.