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The main aim of our project was to formulate and characterize nicotine wafer formulation as an alternate NRT. Millions of people have died and suffered from various diseases like cancer, stroke, blindness, heart problem, and many other chronic diseases by the consumption of raw tobacco and smoking cigarettes.We have developed a nicotine wafer formulation as a type of nicotine replacement therapy (NRT) to aid in smoking cessation. This wafer can help reduce cravings and alleviate withdrawal symptoms for those who are trying to quit smoking or decrease their tobacco consumption.The optimized formula of Nicotine Wafers was generated by the Central composite design under the (RSM) response surface methodology by the DoE method. Mucoadhesion studies were carried out on the prepared optimized formulation to verify the theoretical prediction. The observed values 0.300 kg was in close agreement with the model prediction: bioadhesive strength- 0.306 kg.These finding reveal that the nicotine wafer would be considered as a successful substitute to various market available NRT formulations, due to its rapid absorption characteristics, which would help general public to quit smoking.