Fragment-based Drug Discovery

Lessons and Outlook
Herausgegeben von Erlanson, Daniel A.; Jahnke, Wolfgang; Mannhold, Raimund et al.

• Gebundenes Buch

Produktbeschreibung

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed.

The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.

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Produktdetails

• Methods and Principles in Medicinal Chemistry
• Verlag: Wiley-VCH
• 1. Auflage
• Seitenzahl: 528
• Erscheinungstermin: 13. Januar 2016
• Englisch
• Abmessung: 244mm x 174mm x 28mm
• Gewicht: 1248g
• ISBN-13: 9783527337750
• ISBN-10: 352733775X
• Artikelnr.: 43082543

Autorenporträt

Daniel A. Erlanson is the co-founder and President of Carmot Therapeutics, Inc., which is developing fragment-based approaches to address unmet needs in drug discovery. Prior to Carmot, Dr. Erlanson worked in medicinal chemistry and technology development at Sunesis Pharmaceuticals, which he joined at the company's inception. Before Sunesis, he was an NIH postdoctoral fellow with Dr. James A. Wells at Genentech. Dr. Erlanson earned his Ph.D. in chemistry from Harvard University in the laboratory of Gregory L. Verdine and his BA in chemistry from Carleton College. He edits a blog devoted to fragment-based drug discovery, Practical Fragments.

Wolfgang Jahnke is a Director and Leading Scientist at the Novartis Institutes for Biomedical Research in Basel, Switzerland. His major interests are Structural Biophysics and Fragment-based Drug Discovery. He has received several honors, among them the Industrial Investigator Award from the Swiss Chemical Society, and several Novartis-internal Awards. Dr. Jahnke received his PhD from the TU München, working with Horst Kessler on the development and application of novel NMR methods. Prior to joining Novartis, he worked with Peter Wright at the Scripps Research Institute in La Jolla.

Inhaltsangabe

# 01 The Role of Fragment-Based Approaches in Lead Finding
# 02 Selecting the Right Targets for FBDD
# 03 Enumeration of Chemical Fragment Space
# 04 Ligand Efficiency Metrics and their Use in Fragment Optimizations
# 05 Strategies for Fragment Library Design
# 06 The Synthesis of Biophysical Methods In Support of Robust Fragment-Based Lead Discovery
# 07 Differential Scanning Fluorimetry as Part of a Biophysical Screening Cascade
# 08 Emerging Technologies for Fragment Screening
# 09 Computational Methods to Support Fragment Based Drug Discovery
# 10 Making FBDD Work in Academia
# 11 Site-Directed Fragment Discovery for Allostery
# 12 Fragment Screening in Complex Systems
# 13 Protein-Templated Fragment Ligation Methods: Emerging Technologies in Fragment-Based Drug Discovery
# 14 BACE Inhibitors
# 15 Epigenetics and Fragment Based Drug Discovery
# 16 Discovery of Inhibitors of Protein ? Protein Interactions Using Fragment-Based Methods
# 17 Fragment-Based Discovery of Inhibitors of Lactate Dehydrogenase A
# 18 FBDD Applications to Kinase Drug Hunting
# 19 An Integrated Approach for Fragment Based Lead Discovery: Virtual, NMR and High-Throughput Screening Combined with Structure Guided Design. Application to the Aspartyl Protease Renin.