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Frameworks have been used to provide a profound basis for information systems(IS) development and evaluation for a long time. Contextual frameworks, for example, are frameworks for conceptualizing work practices, business processes and business interaction. An IS framework provides a taxonomy for relating the concepts that describe the real world to the concepts that describe an information system and its implementation. Many of the researchers who have developed IS frameworks do not necessarily go to the extent of validating the relationships indicated therein. Organizational Implementation of Information Systems Innovations (OIISI) Framework was developed in the context of Universities in Kenya and can be used to understand the implementation of Information Systems (IS) Innovations in Higher Education Institutions (HEIs). This book provides a five chapter guide of how this framework was validated and by extension a general procedure that can be used to validate a framework. Testing involved determining the degree of framework associations in HEI context and, in so doing, provided researchers and practitioners with a valid and reliable instrument.