C.W. Reynolds / R.H. Wiltrout (eds.)
Functions of the Natural Immune System
Herausgegeben von Reynolds, C.W.; Wiltrout, R.H.
C.W. Reynolds / R.H. Wiltrout (eds.)
Functions of the Natural Immune System
Herausgegeben von Reynolds, C.W.; Wiltrout, R.H.
- Gebundenes Buch
Produktdetails
- Verlag: Springer, Berlin
- 1989.
- Seitenzahl: 485
- Englisch
- Gewicht: 870g
- ISBN-13: 9780306429514
- ISBN-10: 0306429519
- Artikelnr.: 24551181
- Herstellerkennzeichnung Die Herstellerinformationen sind derzeit nicht verfügbar.
I. Role of the Natural Immune System in the Control of Tumor Cell Growth.- 1 Role of the Natural Immune System in Control of Primary Tumors and Metastasis.- 1. Introduction.- 2. Role of NK Cells in Host Resistance to Primary-Tumor Growth.- 3. NK Cells and Metastatic Growth.- 4. Role of NK Cells in the Antimetastatic Effects of Anticoagulant Drugs.- 5. Major Histocompatibility Complex (MHC) Antigen Expression and NK Sensitivity of Tumor Cells.- 6. Role in Immune Surveillance against Tumors.- 7. Stimulation of Natural Cell-Mediated Immunity and Treatment of Tumor Metastases.- References.- 2 Lymphokine-Activated Killer Cells: Biology and Therapeutic Efficacy.- 1. Introduction.- 2. Characterization and in Vitro Activity of Murine Lymphokine-Activated Killer Cells.- 3. Adoptive Immunotherapy in Murine Tumor Models.- 4. Mechanisms of Adoptive Immunotherapy and Toxicity in the Murine Model.- 5. Characterization of Human Lymphokine-Activated Killer Cells.- 6. Clinical Trials of Lymphokine-Activated Killer Cells and IL-2 in the Therapy of Metastatic Cancer.- 7. Future Prospects and Conclusions.- References.- Summary of Part I.- II. Involvement of the NIS in the Control of Microbial Iinfections.- 3 Natural Effector Cells in Influenza Virus Infection.- 1. Historical Perspective of NK Cells and Influenza Infection.- 2. Interferon and Influenza Infection.- 3. Role of NK Cells during Influenza Virus Infection.- 4. Pathological Consequences of NK Activity.- 5. Conclusions.- References.- 4 Natural Host Defense Systems Active against Herpes Simplex Virus Infections.- 1. Introduction.- 2. Mouse Studies.- 3. Human Studies.- 4. Conclusions.- References.- 5 Factors Influencing the Control of Virus Infections by Natural Killer Cells.- 1. Introduction.- 2. NK-Resistant and NK-Sensitive Viruses.- 3. Age-Dependent Resistance.- 4. Site of Virus Replication.- 5. Interferon-Mediated Effects on Target Cells.- 6. Mechanisms of Selective Lysis of Virus-Infected Target Cells by NK Cells.- 7. Use of NK Cells to Treat Virus Infections.- References.- 6 Natural Killer Cell-Mediated Resistance to Animal Parasites.- 1. Introduction.- 2. Interactions between Natural Killer Cells and Parasites.- 3. Parasites and Antibody-Facilitated Killer Cells.- 4. Conclusions.- References.- 7 Natural Host Resistance Mechanisms against Systemic Mycotic Agents.- 1. Introduction.- 2. Role of Monocytes/Macrophages in Host Defense.- 3. Role of Polymorphonuclear Leukocytes in Host Defense.- 4. Natural Killer Cells and Other Nonphagocytic Effector Cells in Host Defense.- 5. Summary.- References.- 8 Role of Natural Killer Cells in Inflammation and Antibacterial Activity.- 1. Introduction.- 2. Locomotion of Large Granular Lymphocytes.- 3. In Vivo Migratory Responses for Large Granular Lymphocytes/NK Cells.- 4. Can NK Cells Regulate the Inflammatory Response?.- 5. Do NK Cells Have Antibacterial Activity?.- 6. Concluding Remarks.- References.- Summary of Part II.- III. Immunoregulatory Properties of the NIS.- 9 Role of the Natural Immune System in the Antibody Response: Regulatory Effect of NK Cells.- 1. Introduction.- 2. B Cell Differentiation and Antibody Response.- 3. Evidence for Regulation of Antibody Response by NK Cells.- 4. Cellular Interaction in NK Regulation of B Cell Differentiation and Ig Secretion.- 5. Production of Cytokines by NK Cells and Their Role in the Regulation of Antibody Response.- 6. Conclusions and Summary.- References.- 10 Role of Natural Effector Cells in the Regulation of Cell-Mediated Immune Responses.- 1. Introduction.- 2. Characteristics of Natural Immunoregulatory Effector Cells.- 3. Regulation of Cell-Mediated Immune Functions.- 4. Relevance to Disease States.- 5. Summary and Future Directions.- References.- 11 Control of Hematopoietic Progenitor Cells by Natural Killer Cells.- 1. Introduction.- 2. Experimental and Clinical in Vivo Evidence for a Role of NK Cells in Regulation of Hematopoiesis.- 3. Inhibition of in Vitro Hematopoiesis by Human NK Cells
I. Role of the Natural Immune System in the Control of Tumor Cell Growth.- 1 Role of the Natural Immune System in Control of Primary Tumors and Metastasis.- 1. Introduction.- 2. Role of NK Cells in Host Resistance to Primary-Tumor Growth.- 3. NK Cells and Metastatic Growth.- 4. Role of NK Cells in the Antimetastatic Effects of Anticoagulant Drugs.- 5. Major Histocompatibility Complex (MHC) Antigen Expression and NK Sensitivity of Tumor Cells.- 6. Role in Immune Surveillance against Tumors.- 7. Stimulation of Natural Cell-Mediated Immunity and Treatment of Tumor Metastases.- References.- 2 Lymphokine-Activated Killer Cells: Biology and Therapeutic Efficacy.- 1. Introduction.- 2. Characterization and in Vitro Activity of Murine Lymphokine-Activated Killer Cells.- 3. Adoptive Immunotherapy in Murine Tumor Models.- 4. Mechanisms of Adoptive Immunotherapy and Toxicity in the Murine Model.- 5. Characterization of Human Lymphokine-Activated Killer Cells.- 6. Clinical Trials of Lymphokine-Activated Killer Cells and IL-2 in the Therapy of Metastatic Cancer.- 7. Future Prospects and Conclusions.- References.- Summary of Part I.- II. Involvement of the NIS in the Control of Microbial Iinfections.- 3 Natural Effector Cells in Influenza Virus Infection.- 1. Historical Perspective of NK Cells and Influenza Infection.- 2. Interferon and Influenza Infection.- 3. Role of NK Cells during Influenza Virus Infection.- 4. Pathological Consequences of NK Activity.- 5. Conclusions.- References.- 4 Natural Host Defense Systems Active against Herpes Simplex Virus Infections.- 1. Introduction.- 2. Mouse Studies.- 3. Human Studies.- 4. Conclusions.- References.- 5 Factors Influencing the Control of Virus Infections by Natural Killer Cells.- 1. Introduction.- 2. NK-Resistant and NK-Sensitive Viruses.- 3. Age-Dependent Resistance.- 4. Site of Virus Replication.- 5. Interferon-Mediated Effects on Target Cells.- 6. Mechanisms of Selective Lysis of Virus-Infected Target Cells by NK Cells.- 7. Use of NK Cells to Treat Virus Infections.- References.- 6 Natural Killer Cell-Mediated Resistance to Animal Parasites.- 1. Introduction.- 2. Interactions between Natural Killer Cells and Parasites.- 3. Parasites and Antibody-Facilitated Killer Cells.- 4. Conclusions.- References.- 7 Natural Host Resistance Mechanisms against Systemic Mycotic Agents.- 1. Introduction.- 2. Role of Monocytes/Macrophages in Host Defense.- 3. Role of Polymorphonuclear Leukocytes in Host Defense.- 4. Natural Killer Cells and Other Nonphagocytic Effector Cells in Host Defense.- 5. Summary.- References.- 8 Role of Natural Killer Cells in Inflammation and Antibacterial Activity.- 1. Introduction.- 2. Locomotion of Large Granular Lymphocytes.- 3. In Vivo Migratory Responses for Large Granular Lymphocytes/NK Cells.- 4. Can NK Cells Regulate the Inflammatory Response?.- 5. Do NK Cells Have Antibacterial Activity?.- 6. Concluding Remarks.- References.- Summary of Part II.- III. Immunoregulatory Properties of the NIS.- 9 Role of the Natural Immune System in the Antibody Response: Regulatory Effect of NK Cells.- 1. Introduction.- 2. B Cell Differentiation and Antibody Response.- 3. Evidence for Regulation of Antibody Response by NK Cells.- 4. Cellular Interaction in NK Regulation of B Cell Differentiation and Ig Secretion.- 5. Production of Cytokines by NK Cells and Their Role in the Regulation of Antibody Response.- 6. Conclusions and Summary.- References.- 10 Role of Natural Effector Cells in the Regulation of Cell-Mediated Immune Responses.- 1. Introduction.- 2. Characteristics of Natural Immunoregulatory Effector Cells.- 3. Regulation of Cell-Mediated Immune Functions.- 4. Relevance to Disease States.- 5. Summary and Future Directions.- References.- 11 Control of Hematopoietic Progenitor Cells by Natural Killer Cells.- 1. Introduction.- 2. Experimental and Clinical in Vivo Evidence for a Role of NK Cells in Regulation of Hematopoiesis.- 3. Inhibition of in Vitro Hematopoiesis by Human NK Cells