This paper reviewed studies on interventions based on Neurological Reorganization in the autistic spectrum, the main measure discovered by Temple Fay and applied by Glenn Doman and Beatriz Padovan. The justification for the study is based on the scarcity of studies on the subject and the wide discussion about the effectiveness of neurological reorganization previously applied without proof of neuroplasticity. The aim was to carry out a literature review covering the bases that can concretely underpin the method, today supported by neuroscience, and to expose interventions of other kinds as adjuncts in the treatment. Among the main results, this study revealed a very concrete theoretical foundation through neuroscience, although the practice of the Doman-Delacato method is considered controversial and the results of field studies are rather inconclusive. The conclusion suggests a new protocol following the theory now supported by neuroscience and new field studies. This is the second study in a series of three works that seek treatment and raise consistent hypotheses about the origins of the disorder.