Fundamentals of Redox Biology provides a complete introduction to the cellular redox systems, exploring their regulation, physiological role and significance to human diseases. The book begins with a historical overview before exploring the fundamental characteristics and functions of free radicals and reactive oxygen species. Their role in redox signaling and epigenetic regulation are covered, as well as the impact of antioxidants on redox homeostasis. Additionally, the book explores how ROS can lead to oxidative stress and various disease states, including cancer, cardiovascular and…mehr
Fundamentals of Redox Biology provides a complete introduction to the cellular redox systems, exploring their regulation, physiological role and significance to human diseases. The book begins with a historical overview before exploring the fundamental characteristics and functions of free radicals and reactive oxygen species. Their role in redox signaling and epigenetic regulation are covered, as well as the impact of antioxidants on redox homeostasis. Additionally, the book explores how ROS can lead to oxidative stress and various disease states, including cancer, cardiovascular and neurological disorders, while also considering the role of mitochondrial ROS in the immune response against various infections. Biology of cellular redox systems has now become an integral part of many disciplines across the life sciences. This book provides a foundational overview of the topic which will be useful to those in the field of biochemistry, cell biology, molecular biology, immunology, and related areas.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Shyamal Goswami has a research career spanning 35 years. He has experience teaching in biochemistry, cellular and molecular biology and redox biology at the postgraduate level. He served as Associate Professor and Professor in the School of Life Sciences at Jawaharlal Nehru University, India, from 1998 to 2020. Prior to this he was a Research Assistant Professor in the Department of Anatomy and Cell Biology at the State University of New York-Health Science Centre at Brooklyn, New York, USA. Dr. Goswami has contributed numerous publications across his field and has more than 1500 citations. He also co-authored Protocols in Biochemistry and Clinical Biochemistry and co-edited Post-transcriptional Gene Regulation in Human Disease, both published by Academic Press/Elsevier. His main areas of research are cell signaling and gene expression in the cardiovascular system; redox biology of degenerative diseases; and signal scaffolds and cell functions.
Inhaltsangabe
Section A: General topics 1. Free radicals and reactive species in human health and diseases: a historical perspective 2. Biochemistry of free radicals and reactive oxygen species 3. Tools and techniques for the detection and estimation of cellular ROS and other reactive species 4. Redox signaling 5. Role of ROS in genetic and epigenetic regulations 6. Cellular compartmentalization and its importance in the physiological functions of ROS 7. Antioxidants and their physiological roles in redox homeostasis Section B: Specialized topics 8. Role of ROS in metabolism: the cancer cell paradigm 9. ROS and cardiovascular and neurological disorders 10. ROS, the immune response, and its evasion by the pathogens 11. Iron/copper homeostasis, ROS and ferroptosis 12. Role of cellular redox in organismal biology: lessons from yeast, C elegans, Zebrafish, and Drosophila 13. Role of ROS in plant development and stress responses
Section A: General topics 1. Free radicals and reactive species in human health and diseases: a historical perspective 2. Biochemistry of free radicals and reactive oxygen species 3. Tools and techniques for the detection and estimation of cellular ROS and other reactive species 4. Redox signaling 5. Role of ROS in genetic and epigenetic regulations 6. Cellular compartmentalization and its importance in the physiological functions of ROS 7. Antioxidants and their physiological roles in redox homeostasis Section B: Specialized topics 8. Role of ROS in metabolism: the cancer cell paradigm 9. ROS and cardiovascular and neurological disorders 10. ROS, the immune response, and its evasion by the pathogens 11. Iron/copper homeostasis, ROS and ferroptosis 12. Role of cellular redox in organismal biology: lessons from yeast, C elegans, Zebrafish, and Drosophila 13. Role of ROS in plant development and stress responses
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