David R. Sibley
G Protein-Coupled Receptor--Protein Interactions
Herausgegeben:George, Susan R.; O'Dowd, Brian F.
David R. Sibley
G Protein-Coupled Receptor--Protein Interactions
Herausgegeben:George, Susan R.; O'Dowd, Brian F.
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G Protein Coupled Receptor-Protein Interactions examines how GPCRs organize signal transduction and control intracellular activities. Chapters written by recognized experts in each respective topic offer state-of-the-art updates on principles and technology within this discipline, as well as stepwise protocols for methods currently applied to the analysis of protein-receptor interactions.
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G Protein Coupled Receptor-Protein Interactions examines how GPCRs organize signal transduction and control intracellular activities. Chapters written by recognized experts in each respective topic offer state-of-the-art updates on principles and technology within this discipline, as well as stepwise protocols for methods currently applied to the analysis of protein-receptor interactions.
Produktdetails
- Produktdetails
- Receptor Biochemistry and Methodology
- Verlag: Wiley & Sons
- Artikelnr. des Verlages: 14623546000
- 1. Auflage
- Seitenzahl: 352
- Erscheinungstermin: 1. März 2005
- Englisch
- Abmessung: 258mm x 180mm x 22mm
- Gewicht: 815g
- ISBN-13: 9780471235460
- ISBN-10: 0471235466
- Artikelnr.: 13485978
- Receptor Biochemistry and Methodology
- Verlag: Wiley & Sons
- Artikelnr. des Verlages: 14623546000
- 1. Auflage
- Seitenzahl: 352
- Erscheinungstermin: 1. März 2005
- Englisch
- Abmessung: 258mm x 180mm x 22mm
- Gewicht: 815g
- ISBN-13: 9780471235460
- ISBN-10: 0471235466
- Artikelnr.: 13485978
SUSAN R. GEORGE, PhD, MD, FRCP, FACP, is Professor in the Departments of Medicine and Pharmacology at the University of Toronto and a Section Head of Molecular Pharmacology at the Centre for Addiction and Mental Health, Toronto. BRIAN F. O'DOWD, PhD, is Professor in the Department of Pharmacology at the University of Toronto and a Section Head of Molecular Pharmacology at the Centre for Addiction and Mental Health, Toronto.
Foreword (Robert J. Lefkowitz). Series Preface (David R. Sibley). Preface
(Susan R. George & Brian F. O'Dowd). Contributors. 1. Purification of the G
Protein-Coupled Receptor Rhodopsin for Structural Studies (David Salom,
Ning Li, Li Zhu, Izabela Sokal and Krzysztof Palczewski). 2. Cooperativity
in Ligand Binding to Deduce Receptor/Receptor Interaction (Meritxell Vivo
and Philip G. Strange). 3. Analysis of Receptor-Receptor Interaction Using
Time-Resolved Fluorescence Resonance Energy Transfer (Douglas Ramsay and
Graeme Milligan). 4. Real-Time Imaging of GPCR-Medicated Arresting
Translocation as a Strategy to Evaluate Receptor-Protein Interactions
(Robert H. Oakley, Larry S. Barak and Marc G. Caron). 5. Localization of G
Protein Coupled Receptors and Interacting Proteins in Membrane Microdomains
(K. Saidas Nair, Vijaya Narayanan and Vladlen Z. Slepak). 6. Identification
of Peptide Ligand Binding Domains Within G Protein-Coupled Receptors Using
Photoaffinity Labeling (Maoqing Dong and Laurence J. Miller). 7. Analysis
in Real-Time of the Assembly and Disassembly of Soluble G Protein-Coupled
Receptor-G Protein Complexes (Seam M. Biggs, Peter I. Simons, Anna Waller,
Terry Founts, Tione Buranda, Eric R. Prossnitz and Larry A. Sklar). 8.
Approaches to Studying Membrane Protein Oligomerization: Use of Cysteine
Cross-Linking Strategies to Analyze Receptor-Receptor Interactions
(Jonathan A. Javitch, Wen Guo and Marisa E. Ring). 9.
Co-Immunoprecipitation as a Strategy to Evaluate Receptor-Receptor or
Receptor-Protein Interactions (Randy A. Hall). 10. Use of MALDI-TOF and
Mass Spectrometry in the Evaluation of Receptor-Protein Interactions (John
R. Raymond, Henry Ayiku, Justin Turner, Andrew Gelasco and John M. Arthur).
11. Use of the Yeast Two-Hybrid System to Detect Receptor-Protein
Interactions (Ridwan Lin, Nadine Kabbani, Alicia Binda, Victor Canfield and
Robert Levenson). 12. GST Fusion Protein and Pull-down Strategies to
Evaluate Receptor-Receptor or Receptor-Protein Interactions (Frank J.S. Lee
and Fang Liu). 13. G-Protein-Coupled Fusion to Monitor Integral Membrane
Protein-Protein Interactions (Henrik Dohlman and Kathleen Ehrhard). 14.
Enzyme-Linked Immunosorbent Assays as Tools in Studying Interactions of
G-Protein-Coupled Receptors (Torsten Schöneberg, Katrin Sangkuhl, Holger
Römpler and Angela Schulz). 15. Electrophysiological Characterization of
GPCR and Ligand-Gated Channel Crosstalk (Tak Pan Wong, Xian-Ming Yu and Yu
Tian Wang). 16. BRET as a Strategy to Evaluate Receptor-Receptor or
Receptor-Protein Interactions (Karen A. Eidne and Kevin D.G. Pfleger).
Index.
(Susan R. George & Brian F. O'Dowd). Contributors. 1. Purification of the G
Protein-Coupled Receptor Rhodopsin for Structural Studies (David Salom,
Ning Li, Li Zhu, Izabela Sokal and Krzysztof Palczewski). 2. Cooperativity
in Ligand Binding to Deduce Receptor/Receptor Interaction (Meritxell Vivo
and Philip G. Strange). 3. Analysis of Receptor-Receptor Interaction Using
Time-Resolved Fluorescence Resonance Energy Transfer (Douglas Ramsay and
Graeme Milligan). 4. Real-Time Imaging of GPCR-Medicated Arresting
Translocation as a Strategy to Evaluate Receptor-Protein Interactions
(Robert H. Oakley, Larry S. Barak and Marc G. Caron). 5. Localization of G
Protein Coupled Receptors and Interacting Proteins in Membrane Microdomains
(K. Saidas Nair, Vijaya Narayanan and Vladlen Z. Slepak). 6. Identification
of Peptide Ligand Binding Domains Within G Protein-Coupled Receptors Using
Photoaffinity Labeling (Maoqing Dong and Laurence J. Miller). 7. Analysis
in Real-Time of the Assembly and Disassembly of Soluble G Protein-Coupled
Receptor-G Protein Complexes (Seam M. Biggs, Peter I. Simons, Anna Waller,
Terry Founts, Tione Buranda, Eric R. Prossnitz and Larry A. Sklar). 8.
Approaches to Studying Membrane Protein Oligomerization: Use of Cysteine
Cross-Linking Strategies to Analyze Receptor-Receptor Interactions
(Jonathan A. Javitch, Wen Guo and Marisa E. Ring). 9.
Co-Immunoprecipitation as a Strategy to Evaluate Receptor-Receptor or
Receptor-Protein Interactions (Randy A. Hall). 10. Use of MALDI-TOF and
Mass Spectrometry in the Evaluation of Receptor-Protein Interactions (John
R. Raymond, Henry Ayiku, Justin Turner, Andrew Gelasco and John M. Arthur).
11. Use of the Yeast Two-Hybrid System to Detect Receptor-Protein
Interactions (Ridwan Lin, Nadine Kabbani, Alicia Binda, Victor Canfield and
Robert Levenson). 12. GST Fusion Protein and Pull-down Strategies to
Evaluate Receptor-Receptor or Receptor-Protein Interactions (Frank J.S. Lee
and Fang Liu). 13. G-Protein-Coupled Fusion to Monitor Integral Membrane
Protein-Protein Interactions (Henrik Dohlman and Kathleen Ehrhard). 14.
Enzyme-Linked Immunosorbent Assays as Tools in Studying Interactions of
G-Protein-Coupled Receptors (Torsten Schöneberg, Katrin Sangkuhl, Holger
Römpler and Angela Schulz). 15. Electrophysiological Characterization of
GPCR and Ligand-Gated Channel Crosstalk (Tak Pan Wong, Xian-Ming Yu and Yu
Tian Wang). 16. BRET as a Strategy to Evaluate Receptor-Receptor or
Receptor-Protein Interactions (Karen A. Eidne and Kevin D.G. Pfleger).
Index.
Foreword (Robert J. Lefkowitz). Series Preface (David R. Sibley). Preface
(Susan R. George & Brian F. O'Dowd). Contributors. 1. Purification of the G
Protein-Coupled Receptor Rhodopsin for Structural Studies (David Salom,
Ning Li, Li Zhu, Izabela Sokal and Krzysztof Palczewski). 2. Cooperativity
in Ligand Binding to Deduce Receptor/Receptor Interaction (Meritxell Vivo
and Philip G. Strange). 3. Analysis of Receptor-Receptor Interaction Using
Time-Resolved Fluorescence Resonance Energy Transfer (Douglas Ramsay and
Graeme Milligan). 4. Real-Time Imaging of GPCR-Medicated Arresting
Translocation as a Strategy to Evaluate Receptor-Protein Interactions
(Robert H. Oakley, Larry S. Barak and Marc G. Caron). 5. Localization of G
Protein Coupled Receptors and Interacting Proteins in Membrane Microdomains
(K. Saidas Nair, Vijaya Narayanan and Vladlen Z. Slepak). 6. Identification
of Peptide Ligand Binding Domains Within G Protein-Coupled Receptors Using
Photoaffinity Labeling (Maoqing Dong and Laurence J. Miller). 7. Analysis
in Real-Time of the Assembly and Disassembly of Soluble G Protein-Coupled
Receptor-G Protein Complexes (Seam M. Biggs, Peter I. Simons, Anna Waller,
Terry Founts, Tione Buranda, Eric R. Prossnitz and Larry A. Sklar). 8.
Approaches to Studying Membrane Protein Oligomerization: Use of Cysteine
Cross-Linking Strategies to Analyze Receptor-Receptor Interactions
(Jonathan A. Javitch, Wen Guo and Marisa E. Ring). 9.
Co-Immunoprecipitation as a Strategy to Evaluate Receptor-Receptor or
Receptor-Protein Interactions (Randy A. Hall). 10. Use of MALDI-TOF and
Mass Spectrometry in the Evaluation of Receptor-Protein Interactions (John
R. Raymond, Henry Ayiku, Justin Turner, Andrew Gelasco and John M. Arthur).
11. Use of the Yeast Two-Hybrid System to Detect Receptor-Protein
Interactions (Ridwan Lin, Nadine Kabbani, Alicia Binda, Victor Canfield and
Robert Levenson). 12. GST Fusion Protein and Pull-down Strategies to
Evaluate Receptor-Receptor or Receptor-Protein Interactions (Frank J.S. Lee
and Fang Liu). 13. G-Protein-Coupled Fusion to Monitor Integral Membrane
Protein-Protein Interactions (Henrik Dohlman and Kathleen Ehrhard). 14.
Enzyme-Linked Immunosorbent Assays as Tools in Studying Interactions of
G-Protein-Coupled Receptors (Torsten Schöneberg, Katrin Sangkuhl, Holger
Römpler and Angela Schulz). 15. Electrophysiological Characterization of
GPCR and Ligand-Gated Channel Crosstalk (Tak Pan Wong, Xian-Ming Yu and Yu
Tian Wang). 16. BRET as a Strategy to Evaluate Receptor-Receptor or
Receptor-Protein Interactions (Karen A. Eidne and Kevin D.G. Pfleger).
Index.
(Susan R. George & Brian F. O'Dowd). Contributors. 1. Purification of the G
Protein-Coupled Receptor Rhodopsin for Structural Studies (David Salom,
Ning Li, Li Zhu, Izabela Sokal and Krzysztof Palczewski). 2. Cooperativity
in Ligand Binding to Deduce Receptor/Receptor Interaction (Meritxell Vivo
and Philip G. Strange). 3. Analysis of Receptor-Receptor Interaction Using
Time-Resolved Fluorescence Resonance Energy Transfer (Douglas Ramsay and
Graeme Milligan). 4. Real-Time Imaging of GPCR-Medicated Arresting
Translocation as a Strategy to Evaluate Receptor-Protein Interactions
(Robert H. Oakley, Larry S. Barak and Marc G. Caron). 5. Localization of G
Protein Coupled Receptors and Interacting Proteins in Membrane Microdomains
(K. Saidas Nair, Vijaya Narayanan and Vladlen Z. Slepak). 6. Identification
of Peptide Ligand Binding Domains Within G Protein-Coupled Receptors Using
Photoaffinity Labeling (Maoqing Dong and Laurence J. Miller). 7. Analysis
in Real-Time of the Assembly and Disassembly of Soluble G Protein-Coupled
Receptor-G Protein Complexes (Seam M. Biggs, Peter I. Simons, Anna Waller,
Terry Founts, Tione Buranda, Eric R. Prossnitz and Larry A. Sklar). 8.
Approaches to Studying Membrane Protein Oligomerization: Use of Cysteine
Cross-Linking Strategies to Analyze Receptor-Receptor Interactions
(Jonathan A. Javitch, Wen Guo and Marisa E. Ring). 9.
Co-Immunoprecipitation as a Strategy to Evaluate Receptor-Receptor or
Receptor-Protein Interactions (Randy A. Hall). 10. Use of MALDI-TOF and
Mass Spectrometry in the Evaluation of Receptor-Protein Interactions (John
R. Raymond, Henry Ayiku, Justin Turner, Andrew Gelasco and John M. Arthur).
11. Use of the Yeast Two-Hybrid System to Detect Receptor-Protein
Interactions (Ridwan Lin, Nadine Kabbani, Alicia Binda, Victor Canfield and
Robert Levenson). 12. GST Fusion Protein and Pull-down Strategies to
Evaluate Receptor-Receptor or Receptor-Protein Interactions (Frank J.S. Lee
and Fang Liu). 13. G-Protein-Coupled Fusion to Monitor Integral Membrane
Protein-Protein Interactions (Henrik Dohlman and Kathleen Ehrhard). 14.
Enzyme-Linked Immunosorbent Assays as Tools in Studying Interactions of
G-Protein-Coupled Receptors (Torsten Schöneberg, Katrin Sangkuhl, Holger
Römpler and Angela Schulz). 15. Electrophysiological Characterization of
GPCR and Ligand-Gated Channel Crosstalk (Tak Pan Wong, Xian-Ming Yu and Yu
Tian Wang). 16. BRET as a Strategy to Evaluate Receptor-Receptor or
Receptor-Protein Interactions (Karen A. Eidne and Kevin D.G. Pfleger).
Index.