G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume…mehr
G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field.
Produktdetails
Produktdetails
Progress in Molecular Biology and Translational Science Volume 89
Dr. Ya-Xiong Tao is currently Professor of Physiology at Auburn University College of Veterinary Medicine in Auburn, Alabama, USA. He has been working on several G protein-coupled receptors, including gonadotropin receptors regulating reproduction, and melanocortin receptors regulating energy and glucose homeostasis. He has published extensively in peer-reviewed biomedical journals and obtained funding for his research from National Institutes of Health, American Diabetes Association and American Heart Association, among others. He has delivered numerous lectures at universities and research institutes in USA, Canada, China, India, and Mexico. He has edited ten volumes, including seven volumes in Progress in Molecular Biology and Translational Science. He teaches several courses, including Physiology, Receptorology, Genomics and Personalized Medicine, and Molecular Endocrinology, for veterinarian, graduate, and undergraduate Honors students.
Inhaltsangabe
1. Diseased G protein-coupled receptors: An Introduction Ya-Xiong Tao 2. GPR56 and its related diseases Xianhua Piao and Ze Tian 3. GnRHR mutations and hypogonadotropic hypogonadism Nicholas de Roux 4. LHR mutations and reproductive disorders Deborah L. Segaloff 5. FSHR mutations and reproductive disorders Ya-Xiong Tao and Deborah L. Segaloff 6. V2R mutations and nephrogenic diabetes insipidus Daniel G. Bichet 7. Calcium-sensing receptor mutations Geoffrey N. Hendy 8. Diseases caused by prostacyclin receptor mutations John Hwa and Kathleen A Martin
1. Diseased G protein-coupled receptors: An Introduction Ya-Xiong Tao 2. GPR56 and its related diseases Xianhua Piao and Ze Tian 3. GnRHR mutations and hypogonadotropic hypogonadism Nicholas de Roux 4. LHR mutations and reproductive disorders Deborah L. Segaloff 5. FSHR mutations and reproductive disorders Ya-Xiong Tao and Deborah L. Segaloff 6. V2R mutations and nephrogenic diabetes insipidus Daniel G. Bichet 7. Calcium-sensing receptor mutations Geoffrey N. Hendy 8. Diseases caused by prostacyclin receptor mutations John Hwa and Kathleen A Martin
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PRAISE FOR THE SERIES "Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal
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