Comprehensive overview of recent discoveries, the current understanding of the biology of GPCRs and their validity as drug targets.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Part I. Advances in GPCR Protein Research: 1. The evolution of the repertoire and structure of G protein-coupled receptors Torsten Schoenberg, Kristin Schroeck, Claudia Staeubert and Andreas Russ; 2. Functional studies of isolated GPCR-G protein complexes in the membrane bilayer of lipoprotein particles Adam J. Kuszak, Xiao Jie Yao, Sören G. F. Rasmussen, Brian K. Kobilka and Roger K. Sunahara; Part II. Oligomerization of GPCRs: 3. GPCR-G protein fusions: use in functional dimerization analysis Graeme Milligan; 4. Time-resolved FRET approaches to study GPCR complexes Jean Phillipe Pin, Damien Maurell, Laetitia Comps-Agrar, Carine Monnier, Marie-Laure Rives, Etienne Doumazane, Philippe Rondard, Thierry Durroux, Laurent Prézeau and Erin Trinquet; 5. Signaling of dopamine receptor homo- and hetero-oligomers Ahmed Hasbi, Brian F. O'Dowd and Susan R. George; 6. Functional consequences of chemokine receptor dimerization Mario Mellado, Carlos Martinez-A. and Jose Miguel Rodgriguez-Frade; Part III. GPCR Signaling Features: 7. G protein functions identified using genetic mouse models Stefan Offermanns; 8. Kinetics of GPCR, G protein and effector activation Peter Hein; 9. RGS-RhoGEFs and other RGS multidomain proteins as effector molecules in GPCR-dependent and GPCR-independent cell signaling José Vázquez-Prado and J. Silvio Gutkind; 10. Adenylyl cyclase isoform-specific signaling of GPCRs Karin F. K. Ejendal, Julie A. Przybyla and Val J. Watts; 11. G protein-independent and ß arrestin-dependent GPCR signaling Zhongzhen Nie and Yehia Daaka; 12. Assays to read GPCR modulation and signaling Ralf Heilker and Michael Wolff; Part IV. Ligand Pharmacology of GPCRs: 13. Quantifying allosteric ligand-receptor interactions Ivan Toma Vranesic and Daniel Hoyer; 14. 7TM Receptor functional selectivity Terry Kenakin; Part V. Physiological Functions and Drug Targeting of GPCRs: 15. Beta adrenergic receptors in cardiovascular and respiratory diseases Michele Ciccarelli, J. Kurt Chuprun and Walter J. Koch; 16. Role of metabotropic glutamate receptors in CNS disorders Richard M. O'Connor and John F. Cryan; 17. S1P receptor agonists, a novel generation of immunosuppressants Rosa Lopez Almagro, Gema Tarrason and Nuria Godessart; 18. Wnt/Frizzled receptor signaling in osteoporosis Georges Rawadi.
Part I. Advances in GPCR Protein Research: 1. The evolution of the repertoire and structure of G protein-coupled receptors Torsten Schoenberg, Kristin Schroeck, Claudia Staeubert and Andreas Russ; 2. Functional studies of isolated GPCR-G protein complexes in the membrane bilayer of lipoprotein particles Adam J. Kuszak, Xiao Jie Yao, Sören G. F. Rasmussen, Brian K. Kobilka and Roger K. Sunahara; Part II. Oligomerization of GPCRs: 3. GPCR-G protein fusions: use in functional dimerization analysis Graeme Milligan; 4. Time-resolved FRET approaches to study GPCR complexes Jean Phillipe Pin, Damien Maurell, Laetitia Comps-Agrar, Carine Monnier, Marie-Laure Rives, Etienne Doumazane, Philippe Rondard, Thierry Durroux, Laurent Prézeau and Erin Trinquet; 5. Signaling of dopamine receptor homo- and hetero-oligomers Ahmed Hasbi, Brian F. O'Dowd and Susan R. George; 6. Functional consequences of chemokine receptor dimerization Mario Mellado, Carlos Martinez-A. and Jose Miguel Rodgriguez-Frade; Part III. GPCR Signaling Features: 7. G protein functions identified using genetic mouse models Stefan Offermanns; 8. Kinetics of GPCR, G protein and effector activation Peter Hein; 9. RGS-RhoGEFs and other RGS multidomain proteins as effector molecules in GPCR-dependent and GPCR-independent cell signaling José Vázquez-Prado and J. Silvio Gutkind; 10. Adenylyl cyclase isoform-specific signaling of GPCRs Karin F. K. Ejendal, Julie A. Przybyla and Val J. Watts; 11. G protein-independent and ß arrestin-dependent GPCR signaling Zhongzhen Nie and Yehia Daaka; 12. Assays to read GPCR modulation and signaling Ralf Heilker and Michael Wolff; Part IV. Ligand Pharmacology of GPCRs: 13. Quantifying allosteric ligand-receptor interactions Ivan Toma Vranesic and Daniel Hoyer; 14. 7TM Receptor functional selectivity Terry Kenakin; Part V. Physiological Functions and Drug Targeting of GPCRs: 15. Beta adrenergic receptors in cardiovascular and respiratory diseases Michele Ciccarelli, J. Kurt Chuprun and Walter J. Koch; 16. Role of metabotropic glutamate receptors in CNS disorders Richard M. O'Connor and John F. Cryan; 17. S1P receptor agonists, a novel generation of immunosuppressants Rosa Lopez Almagro, Gema Tarrason and Nuria Godessart; 18. Wnt/Frizzled receptor signaling in osteoporosis Georges Rawadi.
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