G Protein Coupled Receptors

Trafficking and Oligomerization Volume 521
Herausgegeben:Conn, P. Michael

• Gebundenes Buch

Produktbeschreibung

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high throughput assays for identification of pharmacoperone drugs.

Produktdetails

• Methods in Enzymology Volume 521
• Verlag: Academic Press / Elsevier Science & Technology
• Artikelnr. des Verlages: C2011-0-04260-6
• Seitenzahl: 480
• Erscheinungstermin: 21. Februar 2013
• Englisch
• Abmessung: 26mm x 152mm x 229mm
• Gewicht: 884g
• ISBN-13: 9780123918628
• ISBN-10: 0123918626
• Artikelnr.: 36623096

Inhaltsangabe

GPCR Trafficking





1. Therapeutic Rescue of Misfolded/Mistrafficked Mutants: Automation-Friendly High Throughput Assays for Identification of Pharmacoperone Drugs of GPCRs
2. Trafficking of the Follitropin Receptor
3. Single Molecule Imaging Technique to Study the Dynamic Regulation of GPCR Function at the Plasma Membrane
4. GPCR Oligomerization and Receptor Trafficking
5. b-Arrestins and G Protein-Coupled Receptor Trafficking
6. Tracking Cell Surface Mobility of GPCRs Using ?-Bungarotoxin Linked Fluorophores
7. Regulatory Mechanism of G Protein-Coupled Receptor Trafficking to the Plasma Membrane: A Role for mRNA Localization
8. Dissecting Trafficking and Signaling of Atypical Chemokine Receptors


Trafficking Motifs




9. Systematic and Quantitative Analysis of G Protein-Coupled Receptor Trafficking Motifs
10. Identification of Endoplasmic Reticulum Export Motifs for G Protein-Coupled Receptors
11. Amino Acid Residues of G-Protein Coupled Receptors Critical for Endoplasmic Reticulum Export and Trafficking


GPCR Oligomerization




12. G Protein-Coupled Heteromers Regulation in Disease
13. Hetero-Oligomerization and Specificity Changes of G Protein-Coupled Purinergic Receptors: Novel Insight into Diversification of Signal Transduction
14. Bimolecular Fluorescence Complementation Analysis of G Protein-Coupled Receptor Dimerization in Living Cells
15. G-Protein Coupled Receptor Heterodimerization in the Brain
16. Experimental Strategies for Studying G Protein-Coupled Receptor Homo- and Heteromerization with Radioligand Binding and Signal Transduction Methods
17. Analysis of GPCRs Dimerization Using Acceptor Photobleaching Resonance Energy Transfer Techniques
18. Techniques for the Discovery of GPCR-Associated Protein Complexes
19. Expression, Purification and Analysis of GProtein-Coupled Receptor Kinases
20. Modern Methods to Investigate the Oligomerization of Glycoprotein Hormone Receptors (TSHR,LHR, FSHR)