Ehab Aboueladab

Galectin-1 and apoptosis

Induction of apoptosis in galectin-1 stimulated Jurkat T lymphocytes

• Broschiertes Buch

Produktbeschreibung

Galectin-1 (gal-1), a member of the family of beta galactoside binding proteins, participates in several biological processes such as immunomodulation, cell adhesion, regulation of cell growth and apoptosis. The aim of this study was to investigate whether gal-1 the mechanisms of T cell activation on the level of signal transduction induced by galectin-1 (gal-1) having immunosuppressive activity. Gal-1 recognizes and cross-links appropriate glycoepitopes (Gal 1- 4GlcNAc- sequences) on T cell activation markers (CD2, CD3, CD45) and stimulates in parallel several interacting signalling pathways leading to suppression of the expression of Th1 cytokines and to apoptosis in thymocytes, activated T- cells, and in leukemic T cell lines. In cellular models by applying cell- and glycobiological methods we have focused on gal-1 induced or suppressed signalling pathways involved in inhibition of a processive immune response of antigen-stimulated T lymphocytes. In this way, by depletion of activated T cells gal-1 is a negative regulator of the immune response. Therefore, the mechanism of gal-1 induced T cell apoptosis is of special interest.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 144
• Erscheinungstermin: 7. Mai 2010
• Englisch
• Abmessung: 220mm x 150mm x 9mm
• Gewicht: 233g
• ISBN-13: 9783838334837
• ISBN-10: 3838334833
• Artikelnr.: 29769160

Autorenporträt

Received his degree as a Bachelor of Science and Education in Chemistry and Physics, his Bachelor of Science in Chemistry and his M.Sc. degree in Biochemistry at the Mansoura University. He is now working as an assistant lecturer in the Home Economics Department of the same University.