Motivation and playfulness are one of those key elements in people's learning that must be promoted in any educational process. This study presents the results of a pedagogical methodology implemented in a virtual course, which integrates the principles of the theory of Conceptual Meaningful Learning, elements of gamification together with the potential of the Moodle platform, in the search of offering a potentially motivating environment for students that leads to active learning. This book shows that it is possible to have fun while learning without compromising the quality of learning.