The problem of gastric cancer, with its multifaceted aspects, offers an example of diversified oncological research, which includes epidemiology, pathogenesis, histo morphology, surgical and conservative therapy in its spectrum. This disease not only constitutes an interesting and important subject for research, but it is also a challenge for the practitioner due to its inordinately poor prognosis. It therefore appeared a rewarding task to the editors to collect information from individual experts, in order to gain a topical summary of the problems pertaining to gastric cancer, as well as to…mehr
The problem of gastric cancer, with its multifaceted aspects, offers an example of diversified oncological research, which includes epidemiology, pathogenesis, histo morphology, surgical and conservative therapy in its spectrum. This disease not only constitutes an interesting and important subject for research, but it is also a challenge for the practitioner due to its inordinately poor prognosis. It therefore appeared a rewarding task to the editors to collect information from individual experts, in order to gain a topical summary of the problems pertaining to gastric cancer, as well as to provide a survey of the progress and the therapeutic possibilities in this field. This task was particularly enticing, as gastric cancer has lately come to belong to those tumors somewhat relegated to the shadows, although it is, despite its decreased fre quency in some western countries, still one of the most prevalent malignant diseases. This collection should emphasize the need for broadlybased knowledge of individual problems as a prerequisite for any satisfactory therapy of an organ tumor. It is therefore the primary concern of this book to furnish anyone with an interest in oncology with this necessary survey. The editors thank Mrs. Karin Dohmeier and Mrs. Karin Kluge from Springer-Verlag for their cooperation in preparing this monograph. We extend our thanks to Mrs. Susanne Schenk and Mrs. Marga Wild, who contributed so much by her secretarial experience for the success of this volume. lJIm,September1979 Ch. Herfarth P. Schlag Table of Contents 1 Epidemiology and Pathogenesis . . . . . . . . . . .Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
1 Epidemiology and Pathogenesis.- Exogenous Factors in the Epidemiology of Gastric Carcinoma.- Pathogenesis of Gastric Carcinoma: The Role of the Microenvironment.- Carcinoma of the Stomach in Urbanized Black South Africans.- Carcinogenic Substances and Carcinogenesis - Their Clinical Significance.- Summary: Epidemiology and Pathogenesis of Gastric Cancer.- 2 Experimental Gastric Cancer.- Experimental Gastric Cancer: Pathogenesis and Clinico-Histopathologic Correlation.- Epithelium at the Gastroenteral Borderline - Comparison of Animal Experiments and Clinical-Pathological Investigations.- Experimental Cancer of the Gastric Stump.- Formal Pathogenesis of Chemically-Induced Cancers After Gastric Operation.- Vagotomy and Gastric Cancer.- Susceptibility to Experimental Gastric Ulcer - Experimental Gastric Cancer, and Gastric Region.- Summary: Experimental Gastric Cancer.- 3 Precancerous Lesions of Gastric Cancer.- Histology of Possible Precancerous Stages in the Stomach.- Dysplastic Changes in Intestinal Metaplasia of the Gastric Mucosa.- Biological Significance of Dysplasias of the Epithelium and of Atrophic Gastritis.- Significance and Location of Atrophic Gastritis and of Glandular Dysplasia in Benign and Malignant Gastric Disease.- Endoscopic Therapy of Gastric Precancerosis.- Summary: Precancerous Lesions of Gastric Cancer.- 4 Risk Factors for Gastric Cancer.- Duodenogastric Reflux and Epithelial Lesions.- Nitrite and N-Nitroso-Compounds in the Operated Stomach.- Risk of Carcinoma in the Gastric Remnant After Gastric Resection for Benign Conditions.- Remarks on Frequency and Pathogenesis of Primary Gastric Stump Cancer.- Prospective Studies in Patients with Resected Stomach and Stump Carcinoma.- Gastric Polyps and Gastric Cancer.- Summary: Risk Factors inGastric Cancer.- 5 Diagnostic Procedures for Classification of Gastric Cancer.- Significance of Diagnostic Procedures for Preoperative Staging.- Biological Markers for Staging of Gastric Cancer?.- Typing, Grading, and Staging of Gastric Carcinoma.- Summary: Diagnostic Procedures for Gastric Cancer.- 6 Prognostic Factors of Gastric Cancer.- Cancer of the Stomach - Prognosis, Independent of Therapy.- Prognostic Significance of Stromal Reaction in Gastric Carcinoma.- A Statistical Trial on Evaluation for Prognosis of Gastric Cancer.- Summary: Prognosis of Gastric Cancer.- 7 Surgical Therapy.- Value of the Gastrectomy "De Principe".- On the Problem of "Stage-Appropriate" Treatment of Gastric Cancer.- Local Excision - A Therapeutic Procedure in Early Gastric Carcinoma?.- Influence of the Choice of Surgical Procedure in Gastric Cancer on the 5-Year Survival Time.- Problems Associated with the Surgical Treatment of Cancer of the Gastric Stump.- Summary: Surgical Therapy.- 8 The Patient After Total Gastrectomy.- Pathophysiological Consequences of Total Gastrectomy.- Importance of the Duodenal Passage Following Gastrectomy.- Significance of the Duodenum for Carbohydrate Metabolism in Patients After Total Gastrectomy.- Nutritional History in Gastrectomized Patients.- Summary: The Patient After Total Gastrectomy.- 9 Experiences with Various Reconstructive Methods After Total Gastrectomy.- Esophagojejunostomy Following Gastrectomy for Gastric Carcinoma - A Follow-Up Study.- Mortality and Morbidity After Esophagojejunostomy.- Jejunal Interposition.- Jejunal Interposition with Plication.- Esophagojejunoplication.- Comparative Analysis of Two Types of Gastric Replacement After Total Gastrectomy.- The Jejunal Pouch as Stomach Substitute.- Jejunal Pouch According toHunt-Lawrence-Rodino with Jejunoplication.- Jejunal Pouch After Total Gastrectomy: A Study of Different Substitutes for the Stomach.- Quality of Life and Stomach Replacement.- Summary: Experiences with Various Types of Reconstructive Procedures After Gastrectomy.- 10 Adjuvant Therapeutic Measures.- A Tentative Synopsis of the Nutritional Problems Encountered in Patients Afflicted with Malignant Neoplasia.- Total Parenteral Nutrition in Regional Surgery for Gastric Cancer.- Immunological Changes During a Perioperative Parenteral Hyperalimentation in Gastrointestinal Cancer.- Results of Surgery for Gastric Cancer and Effect of Adjuvant Chemotherapy.- A Controlled Prospective Study of Adjuvant 5-Fluorouracil and BCNU Therapy in Stomach Carcinoma.- Chemotherapy in Advanced Gastric Cancer.- Combination of Radio-Chemotherapy in Patients with Advanced Gastric Cancer.- Summary: Additional Therapy in Gastric Cancer.
1 Epidemiology and Pathogenesis.- Exogenous Factors in the Epidemiology of Gastric Carcinoma.- Pathogenesis of Gastric Carcinoma: The Role of the Microenvironment.- Carcinoma of the Stomach in Urbanized Black South Africans.- Carcinogenic Substances and Carcinogenesis - Their Clinical Significance.- Summary: Epidemiology and Pathogenesis of Gastric Cancer.- 2 Experimental Gastric Cancer.- Experimental Gastric Cancer: Pathogenesis and Clinico-Histopathologic Correlation.- Epithelium at the Gastroenteral Borderline - Comparison of Animal Experiments and Clinical-Pathological Investigations.- Experimental Cancer of the Gastric Stump.- Formal Pathogenesis of Chemically-Induced Cancers After Gastric Operation.- Vagotomy and Gastric Cancer.- Susceptibility to Experimental Gastric Ulcer - Experimental Gastric Cancer, and Gastric Region.- Summary: Experimental Gastric Cancer.- 3 Precancerous Lesions of Gastric Cancer.- Histology of Possible Precancerous Stages in the Stomach.- Dysplastic Changes in Intestinal Metaplasia of the Gastric Mucosa.- Biological Significance of Dysplasias of the Epithelium and of Atrophic Gastritis.- Significance and Location of Atrophic Gastritis and of Glandular Dysplasia in Benign and Malignant Gastric Disease.- Endoscopic Therapy of Gastric Precancerosis.- Summary: Precancerous Lesions of Gastric Cancer.- 4 Risk Factors for Gastric Cancer.- Duodenogastric Reflux and Epithelial Lesions.- Nitrite and N-Nitroso-Compounds in the Operated Stomach.- Risk of Carcinoma in the Gastric Remnant After Gastric Resection for Benign Conditions.- Remarks on Frequency and Pathogenesis of Primary Gastric Stump Cancer.- Prospective Studies in Patients with Resected Stomach and Stump Carcinoma.- Gastric Polyps and Gastric Cancer.- Summary: Risk Factors inGastric Cancer.- 5 Diagnostic Procedures for Classification of Gastric Cancer.- Significance of Diagnostic Procedures for Preoperative Staging.- Biological Markers for Staging of Gastric Cancer?.- Typing, Grading, and Staging of Gastric Carcinoma.- Summary: Diagnostic Procedures for Gastric Cancer.- 6 Prognostic Factors of Gastric Cancer.- Cancer of the Stomach - Prognosis, Independent of Therapy.- Prognostic Significance of Stromal Reaction in Gastric Carcinoma.- A Statistical Trial on Evaluation for Prognosis of Gastric Cancer.- Summary: Prognosis of Gastric Cancer.- 7 Surgical Therapy.- Value of the Gastrectomy "De Principe".- On the Problem of "Stage-Appropriate" Treatment of Gastric Cancer.- Local Excision - A Therapeutic Procedure in Early Gastric Carcinoma?.- Influence of the Choice of Surgical Procedure in Gastric Cancer on the 5-Year Survival Time.- Problems Associated with the Surgical Treatment of Cancer of the Gastric Stump.- Summary: Surgical Therapy.- 8 The Patient After Total Gastrectomy.- Pathophysiological Consequences of Total Gastrectomy.- Importance of the Duodenal Passage Following Gastrectomy.- Significance of the Duodenum for Carbohydrate Metabolism in Patients After Total Gastrectomy.- Nutritional History in Gastrectomized Patients.- Summary: The Patient After Total Gastrectomy.- 9 Experiences with Various Reconstructive Methods After Total Gastrectomy.- Esophagojejunostomy Following Gastrectomy for Gastric Carcinoma - A Follow-Up Study.- Mortality and Morbidity After Esophagojejunostomy.- Jejunal Interposition.- Jejunal Interposition with Plication.- Esophagojejunoplication.- Comparative Analysis of Two Types of Gastric Replacement After Total Gastrectomy.- The Jejunal Pouch as Stomach Substitute.- Jejunal Pouch According toHunt-Lawrence-Rodino with Jejunoplication.- Jejunal Pouch After Total Gastrectomy: A Study of Different Substitutes for the Stomach.- Quality of Life and Stomach Replacement.- Summary: Experiences with Various Types of Reconstructive Procedures After Gastrectomy.- 10 Adjuvant Therapeutic Measures.- A Tentative Synopsis of the Nutritional Problems Encountered in Patients Afflicted with Malignant Neoplasia.- Total Parenteral Nutrition in Regional Surgery for Gastric Cancer.- Immunological Changes During a Perioperative Parenteral Hyperalimentation in Gastrointestinal Cancer.- Results of Surgery for Gastric Cancer and Effect of Adjuvant Chemotherapy.- A Controlled Prospective Study of Adjuvant 5-Fluorouracil and BCNU Therapy in Stomach Carcinoma.- Chemotherapy in Advanced Gastric Cancer.- Combination of Radio-Chemotherapy in Patients with Advanced Gastric Cancer.- Summary: Additional Therapy in Gastric Cancer.
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