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This book is a reflection of my thesis work submitted during my post graduation study. It highlights the association of Helicobacter pylori with various gastroduodenal diseases. Helicobacter pylori has been declared as a carcinogen by WHO and early detection of this organism in cases of dyspepsia not responding to conventional treatment, helps in preventing progression of such cases to malignancy. Early detection and treatment strategies will help in better management of patients.