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This issue of Critical Care Clinics focuses on Gastrointestinal Critical Care. Articles include: Non variceal Upper Gastrointestinal bleeds; Lower Gastrointestinal bleeds; Mesenteric Ischemia; Peritonitis; The open abdomen and intra abdominal infections; Gut motility issues in critical illness; Gut as the motor of multiple organ dysfunction; Intra abdominal hypertension and abdominal compartment syndrome; Abdominal circulatory interactions in critical illness; Severe acute pancreatitis and necrotizing pancreatitis; and Nutrition in the critically ill.