Gastroretentive Floating Drug Delivery System of Olmesartan Medoxomil - Sharma, Anjali;Sharma, Devkant
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The objective of the present study was to develop an optimized gastroretentive floating drug delivery system of Olmesartan Medoxomil and investigate the effect of hydrophilic retardant on invitro release by using 32 full factorial design. Floating tablets of olmesartan medoxomil were prepared by direct compression method using effervescent technique by employing two different grades of HPMC. (HPMC K4M and HPMC K100M). Sodium bicarbonate was incorporated as gas generating agent. The concentration of HPMC K4M (X1) and concentration of HPMC K100M (X2) were selected as independent variables.The…mehr

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Produktbeschreibung
The objective of the present study was to develop an optimized gastroretentive floating drug delivery system of Olmesartan Medoxomil and investigate the effect of hydrophilic retardant on invitro release by using 32 full factorial design. Floating tablets of olmesartan medoxomil were prepared by direct compression method using effervescent technique by employing two different grades of HPMC. (HPMC K4M and HPMC K100M). Sodium bicarbonate was incorporated as gas generating agent. The concentration of HPMC K4M (X1) and concentration of HPMC K100M (X2) were selected as independent variables.The floating lag time, total floating time and time taken to 80 % drug release were selected as dependent variables. Targets were defined for each response so as to select the optimim formula using numerical optimization. All the floating matrix tablets formulations were subjected to pre-compression and post-compression parameter evaluation.
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Autorenporträt
Anjali Sharma is presently working as Assistant Professor at Guru Gobind Singh College of Pharmacy. Her field of specialization is Pharmaceutics. She has 7 plus years of teaching experience.Devkant Sharma is presently working as Associate Professor at CH. Devi Lal College of Pharmacy, Yamunanagar. His field of specialization is Pharmaceutis.