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Gastric Emptying is a complex process,which is highly variable and makes in-vivo performance of the drug delivery systems uncertain. In order to avoid this variability,efforts have been made to increase the retention time of the drug delivery systems for more than 12 hours. The floating or gastroretentive controlled drug delivery systems are useful in such applications. The present work adresses the physiology of the gastric emptying process with respect to gastroretentive drug delivery systems.