Genes & Cancer: Myc: A Far-Reaching Cancer Gene: Volume 1, Issue 6; June 2010

Herausgeber: Dang, Chi van

• Broschiertes Buch

Produktbeschreibung

As one of the first oncogenes identified, Myc has enjoyed an illustrious history. In reflection of 30 years of research and in excess of 20,000 published articles, two major themes emerge. First, the fine-tuned regulation and numerous activities of Myc in normal cells are unparalleled and a beauty to behold. Second, when this regulation is lost, Myc rears its beastly head and takes the role of one of the most prominent and intriguing of oncoproteins. (From Myc: The Beauty and the Beast by Amanda R. Wasylishen and Linda Z. Penn in Genes & Cancer Vol 1 No 6, 2010.) MYC-A Far-Reaching Cancer Gene edited by Dr. Chi Van Dang at Johns Hopkins is a truly outstanding compilation of comprehensive reviews ("Monographs") that addresses the myriad roles of this very important oncogene in growth, development, metabolism, and cancer. As Dr. Dang states in his introductory remarks, "This special issue captures the excitement that is associated with MYC-mediated tumorigenesis through reviews that span a timeline of MYC research including a fundamental understanding of how the MYC gene itself is regulated, the study of Myc in model organisms, Myc function, and target genes to translational research in search of new therapeutic modalities for the treatment of cancer."

Produktdetails

• Verlag: Sage Publications
• Erscheinungstermin: August 2010
• Englisch
• ISBN-13: 9781412994996
• ISBN-10: 1412994993
• Artikelnr.: 33090345

Inhaltsangabe

Enigmatic MYC Conducts an Unfolding Systems Biology Symphony - Chi V. Dang
Myc: The Beauty and the Beast - Amanda R. Wasylishen and Linda Z. Penn
Myc Function in Drosophila - Paola Bellosta and Peter Gallant
"You Don't Muck with MYC" - David Levens
Chromosome 8q24-Associated Cancers and MYC - Chiara Grisanzio and Matthew
L. Freedman
Emerging Concepts in the Analysis of Transcriptional Targets of the MYC
Oncoprotein: Are the Targets Targetable? - Steven B. McMahon
Myc: Maestro of MicroRNAs - Thi V. Bui and Joshua T. Mendell
Myc Regulation of mRNA Cap Methylation - Victoria H. Cowling and Michael D.
Cole
Transcriptional Repression: The Dark Side of Myc - Barbara Herkert and
Martin Eilers
Myc, Mondo, and Metabolism - Elizabeth J. Sloan and Donald E. Ayer
MYC Inactivation Elicits Oncogene Addiction through Both Tumor
Cell-Intrinsic and Host-Dependent Mechanisms - Dean W. Felsher
Myc Roles in Hematopoiesis and Leukemia - M. Dolores Delgado and Javier
León
Myc and Prostate Cancer - Cheryl M. Koh, Charles J. Bieberich, Chi V. Dang,
William G. Nelson, Srinivasan Yegnasubramanian, and Angelo M. De Marzo
MYC and Breast Cancer - Jinhua Xu, Yinghua Chen, and Olufunmilayo I.
Olopade
Targeting MYC Expression through G-Quadruplexes - Tracy A. Brooks and
Laurence H. Hurley
Therapeutic Targeting of Myc - Edward V. Prochownik and Peter K. Vogt
Targeting MYC-Regulated miRNAs to Combat Cancer - Anna Frenzel, Jakob
Lovén, and Marie Arsenian Henriksson
Genes & Cancer Manuscript Submission Guidelines and Information