Genetic and Phenotypic Markers of Tumors

Herausgegeben:Aaronson, Stuart A.

• Broschiertes Buch

Produktbeschreibung

The study of tumor markers is not only one of the most important but also one that offers one of the richest perspectives in biology and clinical oncology. The aim of scientists in this field is to adduce evidence of a property that is typical of and exclusive to tumor cells, and which is easy to determine, in order to immediately recognize, or even better, to foresee, neoplastic transformations. Unfortunately, despite the large number of scientists and laboratories engaged in this work, the ideal tumor marker has not yet been identified. However, it is worth noting that new trends in molecular biology and immunovirology have recently opened up new avenues that may lead to the eventual resolution of this problem. In this book, different approaches to the identification of tumor markers, from the points of view of biochemistry, immunology, and molecular biology, are compared in order to explore possible interrelationships and to stimulate scientific collaboration among scientists active in these fields, both in basic research and in clinical applications. We wish to thank all the contributors and also the publisher, especially Dr. Robert Andrews, for making the publication of this book possible.

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Produktdetails

• Verlag: Springer / Springer US / Springer, Berlin
• Artikelnr. des Verlages: 978-1-4684-4858-0
• 1984
• Seitenzahl: 396
• Erscheinungstermin: 30. März 2012
• Englisch
• Abmessung: 254mm x 178mm x 22mm
• Gewicht: 742g
• ISBN-13: 9781468448580
• ISBN-10: 1468448587
• Artikelnr.: 39511929

Inhaltsangabe

Phenotypic and Genetic Markers of Cancer: Turning Point in Research.- Phenotypic Markers.- Biochemical Markers.- Multiple Biochemical Markers for Cancer: A Statistical Approach.- Pseudouridine: A Biochemical Marker for Cancer.- Serum Lipid Associated Sialic Acid in Different Human Malignancies: Preliminary Results.- Heterogeneity of Binding Sites for Triphenylethylene Antiestrogens in Estrogen Target Tissues.- Failure to Demonstrate Plasma Hormone Abnormalities in Women with Operable Breast Cancer.- Cell-Type-Independent Accumulation of Phosphatidic Acid Induced by Trifluoperazine in Stimulated Human Platelets, Leukocytes and Fibroblasts.- Protease Inhibitors in 3T3 Cells.- Heterogeneity of Extramitochondrial Forms of Aspartate Aminotransferase and Malate Dehydrogenase in Yoshida Ascites Hepatoma Cells.- Detection of Antigenic Markers by Monoclonal Antibodies.- Biology and Immunology of Human Carcinoma Cell Populations.- Monoclonal Antibodies Against Breast Cancer.- Generation of Monoclonal Antibodies Reactive with Human Colon Carcinomas.- Cellular Recognition of Phenotypic Markers.- Reactivity of Cultured Mouse Natural Killer (NK) Cells Against Normal Non-Neoplastic Cells.- Modulating Effects of Thymic Factors on Natural Cell-Mediated Reactivities of Natural and Cyclophosphamide-Treated Mice.- Effect of Inactivated C. Albicans on Natural Killer (NK) Cell Activity and Blastogenesis in Mice.- Antitumor Adjuvants from Candida Albicans: Effects on Human Allogenic T-Cell Responses "In Vitro".- IL-2 and Lymphocytes from Tumor Bearing Mice: A Combinatory Immunotherapy of Tumors.- Hyporesponsiveness of Natural. Killer Activity Induced In Vivo by Multiple Treatment with Maleic Acid Anhydride Divinyl Ether (MVE-2).- Epstein-Barr Virus Markers in Nasopharyngeal Carcinoma.-Modulation of Antigenic Expression.- Interferon-Mediated Regulation of the NK Target Structures of Normal or Lymphoma Cells.- Membrane Changes Induced by Interferons in Human Neoplastic Cells.- Modulation of Ia Antigens by Interferons in Human Lymphoid Cells.- Role of PGE2 Produced by Neoplastic Cells as Modulators of Macrophage Chemotaxis.- The Relationships Between the High Production of Prostaglandins by Tumors and Their Action on Lymphocytes as Suppressive Agents.- Genomic Markers.- Oncogenes and the Neoplastic Process.- Modulation of Thyroid Epithelial Differentiation by Two Viral Oncogenes.- Thyroid Neoplastic Transformation In Vitro and In Vivo.- Immunological Detection of Cellular Targets for V-onc Gene Coded Tyrosine Kinases.- Nucleotide Sequences Homologous to a Cloned Repeated Human DNA Fragment in Human Leukemic DNA's.- Rearrangement and Abnormal Expression of Human c-myc in Acute Lymphocytic Leukemia.- A New Human Erythroleukemic Line: Initial Characterization and Hemin-Induced Erythroid Differentiation.- Presence of Oncogenes in Spontaneous Rat Tumors.- Molecular Biology of HTLV.- High Level Transcription of a Human Gene in HTLV Positive T-Cells: cDNA Cloning and Characterization.- Clinical Features of Human T-Cell Leukemia/Lymphoma Virus (HTLV) Associated T-Cell Neoplasms.- Participants.