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Today, due to economic problems among young people, the age of marriage has increased in society. That's why the marriage age among women of childbearing age is increased which leads to aging eggs and lack of energy will be to create a zygote cell. In this study, MSX1 gene that plays a role in interrupting ovulation there. The study found that genetic variations in this gene with increasing maternal age for pregnancy As well as oocyte cells mother's talent and lifestyle, and diet and ecosystem conditions can have a significant role in the development of pregnancy interruption.