Entire human homeostasis is running on autophagy of biochemical outflow of nucleotides made up of base, sugar & phosphate. This chromosome acts as signalling authority of genetics which controls over the entire biological system as soon as the human takes birth and starts cardiac cycle and ends its journey at the last breath. The total life span of human [male/female] is authorized by genetics. There are enormous ailments found in body that is dependent on mystery of genetics. The genetic disorders follow the running liquid tissues in body. A genetic disorder is a health problem caused by one or more abnormalities in the genome. It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosomal abnormality. Although polygenic disorders are the most common, the term is mostly used when discussing disorders with a single genetic cause, either in a gene or chromosome.The mutation responsible can occur spontaneously before embryonic development (a de novo mutation), or it can be inherited from two parents who are carriers of a faulty gene (autosomal recessive inheritance) or from a parent with the disorder (autosomal dominant inheritance).