Arthur E. Frankel (ed.)

Genetically Engineered Toxins

Herausgeber: Frankel, Arthur

• Gebundenes Buch

Produktbeschreibung

Presenting all preclinical and clinical information available on genetically engineered toxins, this unique, single-source reference provides the most up-to-date methods and practical examples for conducting clinical studies in toxin molecular biology.;Reviewing difficult problems and their solutions, Genetically Engineered Toxins discusses techniques for clo;ning, expressing, and purifying recombinant toxins and genetically modified recombinant toxins; documents structure-function relationships in toxins, including comparative information; supplies theory and illustrations of chimeric toxins; delineates the preclinical assessments of new reagents; and summarizes approaches to drug design.;With over 1100 literature citations, Genetically Engineered Toxins is an invaluable resource for biochemists, molecular biologists, biotechnologists, pharmacologists, toxicologists, X-ray crystallographers, enzymologists, oncologists, hematologists, immunologists, rheumatologists, botanists, and graduate-level students in molecular biology, biotechnology, and clinical oncology courses.

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Produktdetails

• Verlag: CRC Press
• Seitenzahl: 516
• Erscheinungstermin: 19. Juni 1992
• Englisch
• Abmessung: 235mm x 157mm x 35mm
• Gewicht: 980g
• ISBN-13: 9780824784546
• ISBN-10: 0824784545
• Artikelnr.: 22226907

Autorenporträt

Arthur E. Frankel

Inhaltsangabe

Strategies and techniques - general methods
Robert F. Weaver
cloning strategies
Richard Intres and John W. Crabb
protein engineering strategies
Marc Whitlow
general strategies in in vivo animal modelling
Daniel A. Vallera and Bruce R. Blazar; ricin - molecular cloning of ricin
Lynne R. Roberts
et al
expression of plant-derived ribosome-inactivating proteins in heterologous systems
Michael Piatak
Jr
and Noriyuki Habuka
the structure of plant toxins as a guide to rational design
Jon D. Robertus
chemical and genetic characterization of the enzymatic activity associated with ricin A chain
Lawrence Greenfield
chimeric proteins containing ricin A chain
J. Michael Lord
et al; plant hemitoxins - studies on ribosome-inactivating proteins from Saponaria officinalis
Marco R. Soria
et al
cloning and expression of trichosanthin and - momorcharin cDNA
Pang-Chui shaw
et al
cloning and expression of a Luffa ribosome-inactivating-related protein
Bi-Yu Li and S. Ramakrishnan; fungal ribotoxins - the Aspergillus ribonucleolytic toxins (ribotoxins)
Bernard Lamy
et al
an efficient expression system for -sarcin in Escherichia coli
Yaeta Endo
et al; diphtheria toxin - diphtheria toxin cloning and expression in corynebacterium diphtheriae
Lawrence Greenfield
diphtheria toxin expression in Escherichia coli
Lawrence Greenfield
the structure of diphtheria toxin as a guide to rational design
Peter J. Nicholls and Richard J. Youle
protein engineering of diphtheria toxin - development of receptor-specific cytotoxic agents for the treatment of human disease
John R. Murphy
et all
in vivo studies with chimeric toxins - interleukin-2 fusion toxins as immunosuppressive agents
Michael E. Shapiro
et al
initial clinical experiences with an interleukin-2 fusion toxin (DAB 486-IL-2)
Carole M. Meneghetti and C.F. Le Maistre; pseudomonas exotoxins - pseudomonas aeruginosa exotoxin A
G. Jiliani Chaudry
et al
expression of growth factor - toxin fusion proteins
Gwynneth M. Edwards
et al
the structure of pseudomonas exotoxin A as a guide to rational design
Peter J. Nichols and Richard J. Youle
generation of chimeric toxins
David FitzGerald
et al; conclusions - genetically engineered toxins in perspective
Sjur Olsnes and Arthur E. Frankel
Appendix - primary amino acid sequences of toxins
Paul Sehnke and Alexander Tonevistsky.