Genetics of cancer
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High Quality Content by WIKIPEDIA articles! Cancer is a genetic disorder in which the normal control of cell growth is lost. Cancer genetics is now one of the fastest expanding medical specialties. At the molecular level, cancer is caused by mutation in DNA, which result in aberrant cell proliferation. Most of these mutations are acquired and occur in somatic cells. However, some people inherit mutation in the germline. The mutation occur in two classes of cellular genes: oncogenes and tumor suppressor genes. Oncogenes are derived from normal cellular genes called proto-oncogenes.…mehr

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High Quality Content by WIKIPEDIA articles! Cancer is a genetic disorder in which the normal control of cell growth is lost. Cancer genetics is now one of the fastest expanding medical specialties. At the molecular level, cancer is caused by mutation in DNA, which result in aberrant cell proliferation. Most of these mutations are acquired and occur in somatic cells. However, some people inherit mutation in the germline. The mutation occur in two classes of cellular genes: oncogenes and tumor suppressor genes. Oncogenes are derived from normal cellular genes called proto-oncogenes. Proto-oncogenes were first elucidated in RNA tumor viruses and are now known to encode proteins that are crucial for cellular growth regulation. Mutation in cancer cells alter the normal structure and/or expression pattern of the proto-oncogene, generating oncogenic variant forms with altered function. In genetic terms, oncogenic alleles have gain of function mutation.