Cells and viruses maintain a genome capable of multiplication, variation and heredity. A genome consists of chromosomes, each being built up of two complementary strands of nucleic acid known as DNA. Its chemical integrity, however, is under constant assault from metabolic mutagens, such as hydroxy-radicals, endonucleases, radiation, replication errors, and environmental mutagens. From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. The volume begins with DNA replication and continues with replicative DNA repair and…mehr
Cells and viruses maintain a genome capable of multiplication, variation and heredity. A genome consists of chromosomes, each being built up of two complementary strands of nucleic acid known as DNA. Its chemical integrity, however, is under constant assault from metabolic mutagens, such as hydroxy-radicals, endonucleases, radiation, replication errors, and environmental mutagens. From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. The volume begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions. Examples of human diseases are included and the cellular responses to radiation and genotoxic stress affecting whole genomes are reviewed.
Artikelnr. des Verlages: 11373254, 978-3-540-37528-9
2007
Seitenzahl: 512
Erscheinungstermin: 7. November 2006
Englisch
Abmessung: 241mm x 160mm x 33mm
Gewicht: 926g
ISBN-13: 9783540375289
ISBN-10: 3540375287
Artikelnr.: 20946793
Autorenporträt
Dirk-Henner Lankenau, Ladenburg, Germany
Inhaltsangabe
Replication.- Chromosomal DNA Replication: On Replicases, Replisomes, and Bidirectional Replication Factories.- Progress Towards the Anatomy of the Eukaryotic DNA Replication Fork.- DNA Polymerases and Diseases.- Replicative Double-Strand Break Repair.- Facing Stalled Replication Forks: The Intricacies of Doing the Right Thing.- Germline Double-Strand Break Repair and Gene Targeting in Drosophila: A Trajectory System throughout Evolution.- Facets of Double-Strand Break Repair.- Structure and Function of Rad50/SMC Protein Complexes in Chromosome Biology.- Mechanisms of Non-Homologous DNA End Joining:Aspects of In Vitro Assays.- Role of p53 in Double-Strand Break Repair.- The Role of Chromatin Structure and Nuclear Architecture in the Cellular Response to DNA Double-Strand Breaks.- DNA Repair and Pleiotropic Interactions.- DNA Base Damage Recognition and Processing.- Inter- and Supramolecular Interactions of Protein Kinase CK2 and their Relevance for Genome Integrity.- Role of Human Topoisomerase I in DNA Repair and Apoptosis.- Genomic Instability in Fanconi Anaemia and Nijmegen Breakage Syndrome.- Radiation and other Genotoxic Stress.- Induction of DNA Repair Genes in Mammalian Cells in Response to Genotoxic Stress.- Pathways of DNA Double-Strand Break Repair in Mammalian Cells after Ionizing Radiation.- Genomic Instability:Signaling Pathways Orchestrating the Responsesto Ionizing Radiation and Cisplatin.- Ion Irradiation as a Tool to Reveal the Spatiotemporal Dynamics of DNA Damage Response Processes.
Replication.- Chromosomal DNA Replication: On Replicases, Replisomes, and Bidirectional Replication Factories.- Progress Towards the Anatomy of the Eukaryotic DNA Replication Fork.- DNA Polymerases and Diseases.- Replicative Double-Strand Break Repair.- Facing Stalled Replication Forks: The Intricacies of Doing the Right Thing.- Germline Double-Strand Break Repair and Gene Targeting in Drosophila: A Trajectory System throughout Evolution.- Facets of Double-Strand Break Repair.- Structure and Function of Rad50/SMC Protein Complexes in Chromosome Biology.- Mechanisms of Non-Homologous DNA End Joining:Aspects of In Vitro Assays.- Role of p53 in Double-Strand Break Repair.- The Role of Chromatin Structure and Nuclear Architecture in the Cellular Response to DNA Double-Strand Breaks.- DNA Repair and Pleiotropic Interactions.- DNA Base Damage Recognition and Processing.- Inter- and Supramolecular Interactions of Protein Kinase CK2 and their Relevance for Genome Integrity.- Role of Human Topoisomerase I in DNA Repair and Apoptosis.- Genomic Instability in Fanconi Anaemia and Nijmegen Breakage Syndrome.- Radiation and other Genotoxic Stress.- Induction of DNA Repair Genes in Mammalian Cells in Response to Genotoxic Stress.- Pathways of DNA Double-Strand Break Repair in Mammalian Cells after Ionizing Radiation.- Genomic Instability:Signaling Pathways Orchestrating the Responsesto Ionizing Radiation and Cisplatin.- Ion Irradiation as a Tool to Reveal the Spatiotemporal Dynamics of DNA Damage Response Processes.
Replication.- Chromosomal DNA Replication: On Replicases, Replisomes, and Bidirectional Replication Factories.- Progress Towards the Anatomy of the Eukaryotic DNA Replication Fork.- DNA Polymerases and Diseases.- Replicative Double-Strand Break Repair.- Facing Stalled Replication Forks: The Intricacies of Doing the Right Thing.- Germline Double-Strand Break Repair and Gene Targeting in Drosophila: A Trajectory System throughout Evolution.- Facets of Double-Strand Break Repair.- Structure and Function of Rad50/SMC Protein Complexes in Chromosome Biology.- Mechanisms of Non-Homologous DNA End Joining:Aspects of In Vitro Assays.- Role of p53 in Double-Strand Break Repair.- The Role of Chromatin Structure and Nuclear Architecture in the Cellular Response to DNA Double-Strand Breaks.- DNA Repair and Pleiotropic Interactions.- DNA Base Damage Recognition and Processing.- Inter- and Supramolecular Interactions of Protein Kinase CK2 and their Relevance for Genome Integrity.- Role of Human Topoisomerase I in DNA Repair and Apoptosis.- Genomic Instability in Fanconi Anaemia and Nijmegen Breakage Syndrome.- Radiation and other Genotoxic Stress.- Induction of DNA Repair Genes in Mammalian Cells in Response to Genotoxic Stress.- Pathways of DNA Double-Strand Break Repair in Mammalian Cells after Ionizing Radiation.- Genomic Instability:Signaling Pathways Orchestrating the Responsesto Ionizing Radiation and Cisplatin.- Ion Irradiation as a Tool to Reveal the Spatiotemporal Dynamics of DNA Damage Response Processes.
Replication.- Chromosomal DNA Replication: On Replicases, Replisomes, and Bidirectional Replication Factories.- Progress Towards the Anatomy of the Eukaryotic DNA Replication Fork.- DNA Polymerases and Diseases.- Replicative Double-Strand Break Repair.- Facing Stalled Replication Forks: The Intricacies of Doing the Right Thing.- Germline Double-Strand Break Repair and Gene Targeting in Drosophila: A Trajectory System throughout Evolution.- Facets of Double-Strand Break Repair.- Structure and Function of Rad50/SMC Protein Complexes in Chromosome Biology.- Mechanisms of Non-Homologous DNA End Joining:Aspects of In Vitro Assays.- Role of p53 in Double-Strand Break Repair.- The Role of Chromatin Structure and Nuclear Architecture in the Cellular Response to DNA Double-Strand Breaks.- DNA Repair and Pleiotropic Interactions.- DNA Base Damage Recognition and Processing.- Inter- and Supramolecular Interactions of Protein Kinase CK2 and their Relevance for Genome Integrity.- Role of Human Topoisomerase I in DNA Repair and Apoptosis.- Genomic Instability in Fanconi Anaemia and Nijmegen Breakage Syndrome.- Radiation and other Genotoxic Stress.- Induction of DNA Repair Genes in Mammalian Cells in Response to Genotoxic Stress.- Pathways of DNA Double-Strand Break Repair in Mammalian Cells after Ionizing Radiation.- Genomic Instability:Signaling Pathways Orchestrating the Responsesto Ionizing Radiation and Cisplatin.- Ion Irradiation as a Tool to Reveal the Spatiotemporal Dynamics of DNA Damage Response Processes.
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