Veli Makinen (University of Helsinki), Djamal Belazzougui (Centre de Recherche sur lâ Information Scienti, Fabio Cunial (Massachusetts Broad Institute)

Genome-Scale Algorithm Design

Bioinformatics in the Era of High-Throughput Sequencing

• Gebundenes Buch

Produktbeschreibung

Guided by standard bioscience workflows in high-throughput sequencing analysis, this book for graduate students, researchers, and professionals in bioinformatics and computer science offers a unified presentation of genome-scale algorithms. This new edition covers the use of minimizers and other advanced data structures in pangenomics approaches.

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Produktdetails

• Verlag: Cambridge University Press
• 2 Revised edition
• Seitenzahl: 487
• Erscheinungstermin: 12. Oktober 2023
• Englisch
• Abmessung: 250mm x 171mm x 31mm
• Gewicht: 974g
• ISBN-13: 9781009341233
• ISBN-10: 1009341235
• Artikelnr.: 68100288

Autorenporträt

Veli Mäkinen is Professor of Computer Science at the University of Helsinki, where he leads a research team on genome-scale algorithmics. He has taught advanced courses on algorithm design and analysis, string processing, data compression, and algorithmic genome analysis, as well as introductory courses on bioinformatics.

Inhaltsangabe

Part I. Preliminaries: 1. Molecular biology and high-throughput sequencing
2. Algorithm design
3. Data structures
4. Graphs
5. Network flows
Part II. Fundamentals of Biological Sequence Analysis: 6. Alignments
7. Hidden Markov models
Part III. Genome-Scale Index Structures: 8. Classical indexes
9. Burrows-Wheeler indexes
Part IV. Genome-Scale Algorithms: 10. Alignment-based genome analysis
11. Alignment-free genome analysis and comparison
12. Compression of genome collections
13. Fragment assembly
Part V. Applications: 14. Haplotype analysis
15. Pangenomics
16. Transcriptomics
17. Metagenomics
References
Index.